2012 Fiscal Year Final Research Report
Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic Function
| Project/Area Number |
22651085
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
SUGIURA Yukio 同志社女子大学, 薬学部, 教授 (40025698)
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| Co-Investigator(Kenkyū-buntansha) |
NEGI Shigeru 同志社女子大学, 薬学部, 助教 (50378866)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 亜鉛フィンガー / DNA 認識 / DNA 切断 / 触媒機能 / 酵素類似 / 分子設計 / 加水分解 / 機能変換 / 人工設計 |
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| Research Abstract |
On the basis of native zinc finger protein, design and creation of new zinc finger protein possessing catalytic function were performed. Artificial His4-type zinc finger protein was demonstrated to have DNA hydrolytic function. We firstly succeeded in creation of new enzyme-type zinc finger protein.
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