2011 Fiscal Year Final Research Report
Fabrication of cancer cell-specific nanoparticles utilizing the fluidity of cell membranes
| Project/Area Number |
22655050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Hokkaido University |
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Principal Investigator |
NIIKURA Kenichi 北海道大学, 電子科学研究所, 准教授 (40360896)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌細胞 / 細胞膜 / ナノ粒子合成 |
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| Research Abstract |
For the purpose of the diagnosis of cancer cells, we synthesized nanoparticles that can be selectively uptaken into cell membrane with high fluidity. We can demonstrate that the conformational change of surface ligands on gold nanoparticles can promote the aqueous/organic phase transfer of nanoparticles. The nanoparticles were internalized into cells by penetrating a cell membrane directly. This design of surface ligands based on hydrophilic-hydrophobic block type molecules will lead to the creation of a new type of nanoparticle enabling the detection of cancer cells.
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