2011 Fiscal Year Final Research Report
Research of tumor development due to failure in cell competition
| Project/Area Number |
22657033
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAOSA Kazushige 金沢大学, 薬学系, 助教 (70401891)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞競合 / 発癌 / ショウジョウバエ / 発生 / 細胞貪食 / アポトーシス |
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| Research Abstract |
We generated a Drosophila line that lacks receptors responsible for the phagocytic removal of apoptotic cells. These flies had prolonged larval stage, indicating the importance of apoptotic cell clearance in growth. To determine the characteristic of' loser cells', which remain in animals due to a defect in phagocytosis, a mosaic mutation for artificial cell competition was introduced into a phagocytosis-deficient fly line. However, we could not complete the examination of these flies within the allocated research period.
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[Journal Article] Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila2012
Author(s)
Okada, R., Nagaosa, K., Kuraishi, T., Nakayama, H., Yamamoto, N., Nakagawa, Y. Dohmae, N., Shiratsuchi, A., and Nakanishi, Y
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 3138-3146
DOI
Peer Reviewed
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[Journal Article] Integrinβν-mediated phagocytosis of apoptotic cells in Drosophila embryos2011
Author(s)
Nagaosa, K., Okada, R., Nonaka, S., Takeuchi, K., Fujita, Y., Miyasaka, T., Manaka, J., Ando, I., and Nakanishi, Y
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 25770-25777
DOI
Peer Reviewed
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