2011 Fiscal Year Final Research Report
Metabolic regulation through the mechanotransduction pathway
| Project/Area Number |
22657046
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 力学刺激 / 運動 / 心臓 / 筋肉 / ATP |
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| Research Abstract |
In this project, we have found two force-sensitive metabolic regulators. One of them is localized in the adhesion complexes. When cells are stretched, this factor shuttles from the cytoplasm to the nucleus to regulate adipogenic differentiation of stem cells. Another metabolic regulator also shuttles into the nucleus in response to hemodynamic forces to activate nuclear orphan receptors and increase ATP production in heart, hence activate an essential adaptive responses of cardiomyocytes to hemodynamic overload Our data provide novel targets of metabolic regulation.
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[Journal Article] Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.2010
Author(s)
Yuki Hirota, Alice Meunier, Shihhui Huang, Togo Shimozawa, Osamu Yamada, Yasuyuki S Kida, Masashi Inoue, Tsubasa Ito, Hiroko Kato, Masanori Sakaguchi, Takehiko Sunabori, Masa-aki Nakaya, Shigenori Nonaka, Toshihiko Ogura, Hideo Higuchi, Hideyuki Okano, Na
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Journal Title
Development
Volume: 137
Pages: 3037-3046
Peer Reviewed
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