2011 Fiscal Year Final Research Report
A challenge for the Quality Control of Sperm Based on Stem Cell Competition
| Project/Area Number |
22657058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
YOSHIDA Shosei 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 精子形成 / 遺伝情報 / 幹細胞 / 品質保証 / マウス |
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| Research Abstract |
This study has investigated the competition between mouse spermatogenic stem cells that plays a crucial role in the quality control of sperm, by means of pulse label-chase of spermatogenic stem cells in combination with mathematical and statistical analyses. As a result, it has been discovered that stem cells are always turning over with each other and many of the stem cells lose their function while a small number of stem cell cohorts expand, which is contrary to a prevailing thought that stem cells are a few special cell types that always dived asymmetrically. Moreover, it has been discovered that stem cells' turnover occurs in a stochastic manner.
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[Journal Article] Cyclical and patch-like GDNF distribution along the basal surface of sertoli cells in mouse and hamster testes
Author(s)
T. Sato, Y. Aiyama, M. Ishii-Inagaki, K. Hara, N. Tsunekawa, K. Harikae, M. Uemura-Kamata, M. Shinomura, X. B. Zhu, S. Maeda, S. Kuwahara-Otani, A. Kudo, H. Kawakami, M. Kanai-Azuma, M. Fujiwara, Y. Miyamae, S. Yoshida, M. Seki, M. Kurohmaru and Y. Kanai
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Journal Title
PLoS ONE
Volume: 6
Pages: e28367
DOI
Peer Reviewed
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