Development of DDS-carrier for BBB based onsialic acid

2012 Fiscal Year Final Research Report

• Project/Area Number: 22658038
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Bioproduction chemistry/Bioorganic chemistry
• Research Institution: Gifu University
• Principal Investigator: KISO Makoto 岐阜大学, 応用生物科学部, 教授 (90092931)
• Project Period (FY): 2010 – 2012
• Keywords: 生物活性物質

Research Abstract

The DDS in which the medicine are included in the liposome and delivered to the diseased region has already been partially used in practice. However, restriction of drug distribution in to the brain by the blood-brain barrier (BBS) is one of the serious issue for DDS. Based onthe molecular basis for breast cancer metastasis to the brain, the liposome modified with the sialoglycan uniquely found on breast cancer was prepared and applied for the DDS to brain.

Research Products

• [Journal Article] Role of Binding in Mycoplasma mobile and Mycoplasma pneumoniae Gliding Analyzed through Inhibition by Synthesized Sialylated Compounds (2013)
  • Author(s): Kasai, T., Nakane, D., Ishida, H., Ando, H., Kiso, M.and Miyata, M
  • Journal Title: J. Bacteriol Volume: 195 Pages: 429-435
  • Peer Reviewed
• [Journal Article] First synthesis of a pentasaccharide moiety of ganglioside GAA-7 containing unusually modified sialic acids through the use of N-Troc-sialic acid derivative as a key unit (2012)
  • Author(s): Tamai, H., Ando, H., Ishida, H. and Kiso, M
  • Journal Title: Organic Lett Volume: 14 Pages: 6342-6345
  • Peer Reviewed
• [Journal Article] Design and synthesis of a novel ganglioside ligand for influenza A viruses (2012)
  • Author(s): Nohara, T., Imamura, A., Yamaguchi, M., Hidari, K.I.P.J., Suzuki, T., Komori, T., Ando, H., Ishida, H. and Kiso, M
  • Journal Title: Molecules Volume: 17 Pages: 9590-9620
  • Peer Reviewed
• [Journal Article] Efficiently synthesizing lacto-ganglio-series gangliosides by using a glucosyl ceramide cassette approach: the total synthesis of ganglioside X2 (2012)
  • Author(s): Nakashima, S., Ando, H., Saito, R., Tamai, H., Ishida, H. and Kiso, M
  • Journal Title: Chemistry-An Asian J Volume: 7 Pages: 1041-1051
  • Peer Reviewed
• [Journal Article] The first total synthesis of ganglioside GalNAc-GD1a, a target molecule for autoantibodies in Guillain-Barre syndrome (2011)
  • Author(s): Fujikawa, K., Nakashima, S., Konishi, M., Fuse, T., Komura, N., Ando, T., Ando, H., Yuki, N., Ishida, H. and Kiso, M.
  • Journal Title: Chem. Eur. J Volume: 17 Pages: 5641-5651
  • Peer Reviewed
• [Journal Article] A first total synthesis of a hybrid-type ganglioside associated with amyotrophic lateral sclerosis-like disorder (2011)
  • Author(s): Nakashima, S., Ando, H., Imamura, A., Yuki, N., Ishida, H. and Kiso, M
  • Journal Title: Chem. Eur. J Volume: 17 Pages: 588-597
  • Peer Reviewed
• [Journal Article] A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis (2010)
  • Author(s): Fujikawa, K., Nohara, T., Imamura, A., Ando, H., Ishida, H. and Kiso, M
  • Journal Title: Tetrahedron Lett Volume: 51 Pages: 1126-1130
  • Peer Reviewed
• [Presentation] Synthetic gangliosides and analogs: Versatile tools to elucidate the cell functions of sialoglycans (2012)
  • Author(s): Makoto Kiso
  • Organizer: Commemorative Symposium on the 20th Anniversary of the Mizutani Foundation for Glycoscience Glycoscience : diversity and integration～生命多様性の統合的理解に向けた糖質科学～
  • Place of Presentation: 東京コンファレンスセンター・品川(東京)
  • Year and Date: 20121128-29
• [Presentation] PECAM のホモフィリックな相互作用にシアル酸が果たす役割 (2011)
  • Author(s): 今牧理恵, 北爪しのぶ, 小川加寿子, 石田秀治, 安藤弘宗, 木曽真, 谷口直之
  • Organizer: 第30回日本糖質学会
  • Place of Presentation: 長岡リリックホールとハイブ長岡(新潟)
  • Year and Date: 20110711-13
• [Presentation] Novel gangliosides synthesis toward applications in medicinal chemistry and cell biology (2010)
  • Author(s): Kiso, M., Ishida, H. and Ando, H.
  • Organizer: 13th International Conference on Biology and Chemistry of Sialic Acids - SialoGlyco 2010
  • Place of Presentation: Potsdam, Germany
  • Year and Date: 20100821-26
• [Presentation] biological recognition at molecular and cellular levels, and applications in medicinal chemistry (2010)
  • Author(s): Kiso, M., Ishida, H. and Ando, H.: Synthetic sialosides
  • Organizer: Assiut Univ. 7th International Pharmaceutical Science Conference
  • Place of Presentation: Assiut, Egypt
  • Year and Date: 20100317-18
• [Book] Renewed synthetic approach to SAα2-3Galβ1-3GalNAc-R SAα2-3Galβ1-3GalNAc-RSAα26SAα2-3Galβ1-3GalNAc-OR , SAα2-3Galβ1-3GalNAc-ORSAα26ST6GALNAC5gangliosides exploiting versatile and powerful synthetic units, in Methods In Enzymology, Glycomics, F. Minoru, Editor. (2010)
  • Author(s): Ando, H., Ishida, H. and Kiso, M
  • Total Pages: 478
  • Publisher: Elsevier: Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo
• [Book] コールドスプリングハーバー 糖鎖生物学 第2 版 (2010)
  • Author(s): 秋元義弘, 安形高志, 安藤弘宗, 池北雅彦, 石田秀治, 岡島徹也, 掛樋一晃, 神奈木玲児, 木曽真, 北島健, 木下タロウ, 木全弘治, 久野淳, 佐藤ちひろ, 鈴木康夫, 竹川薫, 館野浩章, 谷口直之, 永井尚子, 羽渕脩躬, 浜村和紀, 平林淳, 古川圭子, 古川鋼一, 堀戸重臣, 宮坂昌之, 矢部富雄、山内祥生
  • Publisher: 鈴木康夫、木全弘治監訳, 丸善
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~kassei1/