Role of fatty acid-binding protein in the brain vulnerability in schizophrenia

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659012
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: FUKUNAGA Kohji 東北大学, 大学院・薬学研究科, 教授 (90136721)
• Co-Investigator(Kenkyū-buntansha): MORIGUCHI Shigeki 東北大学, 大学院・薬学研究科, 講師 (70374949)
• Project Period (FY): 2010 – 2011
• Keywords: 薬理学

Research Abstract

H-FABP is associated with D2L receptor in vivo. H-FABP null mice showed increased anxiety and impaired cognitive behavior. The impaired cognitive behavior was associated with decreased CaMKII activities in the cingulate cortex and DHA diet improved the impaired cognitive behaviors in H-FABP null mice. Thus, the decreased CaMKII activity likely mediates impairments of cognitive function in H-FABP null mice. H-FABP null mice are useful to define the role of FABP in the vulnerable of schizophrenia brain.

Research Products

• [Journal Article] Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload induced hypertrophy in ovariectomized female rats (2011)
  • Author(s): Tagashira H, Bhuiyan S, Shioda N, Fukunaga K.
  • Journal Title: Menopause Volume: 18(12) Pages: 1317-26
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21844826
  • Peer Reviewed
• [Journal Article] Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation (2011)
  • Author(s): Oyagi A, Moriguchi S, Nitta A, Murata K, Oida Y, Tsuruma K, Shimazawa M, Fukunaga K, Hara H.
  • Journal Title: Brain Res Volume: 1419 Pages: 97-104
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21945083
  • Peer Reviewed
• [Journal Article] Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor beta-receptor lacking mice (2011)
  • Author(s): Shioda N, Moriguchi S, Oya T, Ishii Y, Shen J, Matsushima T, Nishijo H, Sasahara M, Fukunaga K.
  • Journal Title: Hippocampus
  • DOI: doi:10.1002/hipo.20973.
  • Peer Reviewed
• [Journal Article] CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart (2011)
  • Author(s): Lu YM, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li XM, Han F.
  • Journal Title: PLoS One Volume: 6(9) Pages: e24724
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21931829
  • Peer Reviewed
• [Journal Article] Dopamine D2 receptor as a novel target molecule for heart-type fatty acid binding protein. Nihon Shinkei Seishin Yakurigaku Zasshi (2011)
  • Author(s): Shioda N, Yamamoto Y, Owada Y, Fukunaga K.
  • Volume: 31(3)
  • Pages: 125-30
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21800703
  • Peer Reviewed
• [Journal Article] Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior (2011)
  • Author(s): Shioda N, Yamamoto Y, Han F, Moriguchi S, Fukunaga K.
  • Journal Title: Yakugaku Zasshi Volume: 131(4) Pages: 505-11
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21467789
  • Peer Reviewed
• [Journal Article] Establishment of"evidence based medicine" for the treatment of cerebral stroke-bridging basic and clinical sciences (2011)
  • Author(s): Tokuyama S, Fukunaga K.
  • Journal Title: Yakugaku Zasshi Volume: 131(4) Pages: 503-4
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21467788
  • Peer Reviewed
• [Journal Article] Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice (2011)
  • Author(s): Moriguchi S, Yamamoto Y, Ikuno T, Fukunaga K.
  • Journal Title: J Neurochem Volume: 117(5) Pages: 879-91
  • DOI: doi:10.1111/j.1471-4159.2011.07256.x.
  • Peer Reviewed
• [Journal Article] Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells (2011)
  • Author(s): Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH.
  • Journal Title: J Pineal Res Volume: 51(1) Pages: 124-35
  • DOI: doi:10.1111/j.1600-079X.2011.00869.x.
  • Peer Reviewed
• [Journal Article] Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia (2011)
  • Author(s): Shioda N, Fukunaga K.
  • Journal Title: Yakugaku Zasshi Volume: 131(1) Pages: 13-20
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21212608
  • Peer Reviewed
• [Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII)activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain (2011)
  • Author(s): Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K.
  • Journal Title: J Neurosci Volume: 31(1) Pages: 346-58
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21209221
  • Peer Reviewed
• [Journal Article] Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotection (2011)
  • Author(s): Bhuiyan MS, Fukunaga K.
  • Journal Title: Expert Opin Ther Targets Volume: 15(2) Pages: 145-155
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21204730
  • Peer Reviewed
• [Journal Article] Melatonin ameliorates ischemic-like injury-evoked nitrosative stress : Involvement of HtrA2/PED pathways in endothelial cells (2011)
  • Author(s): Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH
  • Journal Title: J Pineal Res Volume: 50(3) Pages: 281-91
  • DOI: doi:10.1111/j.1600-079X.2010.00838.x.
  • Peer Reviewed
• [Journal Article] Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding (2011)
  • Author(s): Bhuiyan MS, Tagashira H, Fukunaga K.
  • Journal Title: Eur J Pharmacol Volume: 650(2-3) Pages: 621-8
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21044620
  • Peer Reviewed
• [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice (2011)
  • Author(s): Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
  • Journal Title: Hippocampus Volume: 21(6) Pages: 678-87
  • DOI: doi:10.1002/hipo.20782.
  • Peer Reviewed
• [Journal Article] Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy (2011)
  • Author(s): Moriguchi S, Oomura Y, Shioda N, Han F, Hori N, Aou S, Fukunaga K.
  • Journal Title: Mol Cell Neurosci Volume: 46(1) Pages: 101-7
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20807573
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone-mediated stimulation of sigma-1 receptor activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding (2011)
  • Author(s): Bhuiyan MS, Tagashira H, Fukunaga K.
  • Journal Title: Cardiovasc Ther Volume: 29(4) Pages: 219-30
  • DOI: doi:10.1111/j.1755-5922.2010.00196.x.
  • Peer Reviewed
• [Journal Article] Expression profiling of Ca(2+)/calmodulin-dependent signaling molecules in the rat dorsal and ventral hippocampus after acute lead exposure (2010)
  • Author(s): Zhang GS, Ye WF, Tao RR, Lu YM, Shen GF, Fukunaga K, Huang JY, Ji YL, Han F.
  • Journal Title: Exp Toxicol Pathol
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21195594
  • Peer Reviewed
• [Journal Article] CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells (2010)
  • Author(s): Kajihara R, Fukushige S, Shioda N, Tanabe K, Fukunaga K, Inui S.
  • Journal Title: Biochem Biophys Res Commun Volume: 401(3) Pages: 350-5
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20851109
  • Peer Reviewed
• [Journal Article] Sigma1-receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice (2010)
  • Author(s): Tagashira H, Bhuiyan S, Shioda N, Hasegawa H, Kanai H, Fukunaga K.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 299(5) Pages: H1535-45
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20802134
  • Peer Reviewed
• [Journal Article] Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions (2010)
  • Author(s): Bhuiyan MS, Tagashira H, Shioda N, Fukunaga K.
  • Journal Title: Expert Opin Ther Targets Volume: 14(10) Pages: 1009-22
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20722474
  • Peer Reviewed
• [Journal Article] Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders : proteins interacting with the third cytoplasmic loop of dopamine D2 and D3 receptors (2010)
  • Author(s): Shioda N, Takeuchi Y, Fukunaga K.
  • Journal Title: J Pharmacol Sci Volume: 114(1) Pages: 25-31
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20716856
  • Peer Reviewed
• [Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function (2010)
  • Author(s): Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H.
  • Journal Title: PLoS One Volume: 5(7) Pages: e11602
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20657643
  • Peer Reviewed
• [Journal Article] Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice (2010)
  • Author(s): Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K.
  • Journal Title: Yakugaku Zasshi Volume: 130(5) Pages: 717-21
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20460870
  • Peer Reviewed
• [Journal Article] Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats. (2010)
  • Author(s): Bhuiyan S, Fukunaga K.
  • Journal Title: Exp Biol Med (Maywood) Volume: 235(3) Pages: 356-64
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20404054
  • Peer Reviewed
• [Journal Article] Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes (2010)
  • Author(s): Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K.
  • Journal Title: Biochim Biophys Acta Volume: 1799(5-6) Pages: 429-41
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/2021
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice (2010)
  • Author(s): Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T.
  • Journal Title: PLoS One Volume: 5(3) Pages: e9460
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20209163
  • Peer Reviewed
• [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons (2010)
  • Author(s): Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
  • Journal Title: Neurosci Res Volume: 67(2) Pages: 126-36
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20188128
  • Peer Reviewed
• [Journal Article] Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain (2010)
  • Author(s): Shioda N, Yamamoto Y, Watanabe M, Binas B, Owada Y, Fukunaga K.
  • Journal Title: J Neurosci Volume: 30(8) Pages: 3146-55
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20181611
  • Peer Reviewed
• [Journal Article] Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE (2010)
  • Author(s): Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga S.
  • Journal Title: Mol Cell Proteomics Volume: 9(6) Pages: 1133-43
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20097924
  • Peer Reviewed
• [Journal Article] A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice (2010)
  • Author(s): Shioda N, Yamamoto Y, Han F, Moriguchi S, Yamaguchi Y, Hino M, Fukunaga K.
  • Journal Title: J Pharmacol Exp Ther Volume: 333(1) Pages: 43-50
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/2006
  • Peer Reviewed
• [Journal Article] Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl] ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3. 5 hydrate (DY-9 (2010)
  • Author(s): Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K.
  • Journal Title: J Pharmacol Exp The Volume: 332(2) Pages: 421-8
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/19889795
  • Peer Reviewed
• [Journal Article] Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanisms responsible for cardiac decompensation using ovariectomized pressure-overloaded rats (2010)
  • Author(s): Bhuiyan MS, Fukunaga K.
  • Journal Title: Menopause Volume: 17(1) Pages: 213-21
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/19741553
  • Peer Reviewed
• [Presentation] Shioda, Stimulation of sigma-1 receptor improves cognitive functions through CaMKII activation (2011)
  • Author(s): K. Fukunaga, S. Moriguchi, Y. Yamamoto, N.
  • Organizer: Neuroscience2011
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 20111112-16
• [Presentation] ATRX変異精神遅滞マウスにおけるスパイン形態異常 (2011)
  • Author(s): 福永浩司、塩田倫史、別府秀幸、北島勲
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
  • Year and Date: 20110926-28
• [Presentation] MPTP処置パーキンソン病モデルマウスにおける認知機能障害とCaMキナーゼII活性低下の関連性 (2011)
  • Author(s): 森口茂樹、矢吹悌、福永浩司
  • Organizer: 第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 20110915-17
• [Presentation] バナジウム化合物の心臓保護薬としての有用性 (2011)
  • Author(s): 福永浩司、Md. Shenuarin Bhuiyan
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110528-31
• [Presentation] DHEA処置によるシグマ1受容体の活性化は嗅球摘出マウスにおける認知機能障害をCaMKII、PKC、ERKの活性化を介して改善する (2011)
  • Author(s): 森口茂樹、山本由似、生野達也、福永浩司、
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20110522-24
• [Presentation] 肥大心筋細胞におけるSigma-1 受容体による細胞内カルシウム制御 (2011)
  • Author(s): 福永浩司
  • Organizer: 第21回日本循環薬理学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-12-02
• [Presentation] Downregulation of cardiac sigma-1 receptor in transverse aortic constriction (TAC)-induced cardiac hypertrophy (2010)
  • Author(s): Kohji Fukunaga, Hideaki Tagashira
  • Organizer: The 9th Japan-Korea joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Keitenkaku & Hakusui-kan, Kagoshima, Japan
  • Year and Date: 20101125-28
• [Presentation] 脂肪酸結合蛋白質の新しい標的分子としてのドパミンD2受容体 (2010)
  • Author(s): 福永浩司、竹内有輔、塩田倫史
  • Organizer: 第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台
  • Year and Date: 20100915-17
• [Presentation] A novel cognitive enhancer, Spino[Imidazo[1, 2-A] Pyridine-3, 2-Indan]-2(3H)-One (ZSET1446), promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice (2010)
  • Author(s): Kohji Fukunaga, Yui Yamamoto, Shigeki Moriguchi and Norifumi Shioda
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Hawaii, USA
  • Year and Date: 20100710-15
• [Presentation] Memantine ameliorates the impairment of hippocampal long-term potentiation in olfactory bulbectomized mice (2010)
  • Author(s): Shigeki Moriguchi, Yui Yamamoto, Norifumi Shioda and Kohji Fukunaga
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Hawaii, USA
  • Year and Date: 20100710-15
• [Presentation] Shenuarin Md Bhuiyan. Dysregulation of PP1 and CaMKII activities accounts for abnrmal dendritic spine formation in ATRX mental retardation mice (2010)
  • Author(s): Kohji Fukunaga, Norifumi Shioda, Hideaki Tagashira
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100614-18
• [Presentation] CaMキナーゼIIとプロテインキナーゼCの活性化を介したPAFによる海馬シナプス伝達の増強 (2010)
  • Author(s): 森口茂樹、福永浩司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100516-18
• [Presentation] 新規アルツハイマー治療薬の認知機能改善とうつ症状改善作用の神経機序 (2010)
  • Author(s): 福永浩司、塩田倫史、山本由似、森口茂樹
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 20100328-30
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/~yakuri/yakuri_top.html