2011 Fiscal Year Final Research Report
Prediction of immune disorders by evaluation of serum IgG reactivity to random peptide library
| Project/Area Number |
22659057
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫制御 / 抗体 / 自己免疫疾患 / アレルギー / 炎症 |
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| Research Abstract |
Based on an assumption that reactivities of natural antibodies in sera will be changed before and after onset of immune disorders such as autoimmune diseases, we first analyzed the effect of human polyclonal IgG preparations on immune cell functions such as that of B cells. We found that F(ab')_2 fragment of IgG can bind to various cell surfaces and swiftly internalized into the cytosol. Interestingly, the polyclonal IgG was able to suppress cytokine production from B cells stimulated with CpG.
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[Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.2011
Author(s)
Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
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Journal Title
Arthritis Rheum
Volume: 63(10)
Pages: 2930-8
DOI
Peer Reviewed
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[Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9. MyD88 in lung CD11b+ CD11c+ cells2011
Author(s)
Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
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Journal Title
Eur. Respir. J
Volume: erj01771-2010
DOI
Peer Reviewed
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[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011
Author(s)
Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A
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Journal Title
J. Exp. Med
Volume: (in press)
Peer Reviewed
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[Journal Article] The inhibitory effects of intravenous administration of rabbit IgG on airway inflammation are dependent on Fcgamma receptor IIb on CD11c+ dendritic cells in murine model2010
Author(s)
Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y
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Journal Title
Clin. Exp. Immunol
Volume: 162(2)
Pages: 315-24
DOI
Peer Reviewed
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[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney 1ischemia/reperfusion injury2010
Author(s)
Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T
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Journal Title
J. Exp. Med
Volume: 207(7)
Pages: 1501-11
Peer Reviewed
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