2011 Fiscal Year Final Research Report
Development of new regeneration therapy by targeting of miRNA
| Project/Area Number |
22659079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IIZASA Hisashi 北海道大学, 遺伝子病制御研究所, 助教 (80306662)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 幹細胞 / 再生医療 / miRNA / がん幹細胞 |
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| Research Abstract |
To develop new regeneration therapy by targeting of miRNA, we generated cancer stem cell isolation system which detect stem cell-specific transcription factor expressions. We isolated SOX2 promoter activity positive cell population from MCF-7 and this population showed high activity of sphere formation compare with its control. This result indicates that the expression of stem cell specific transcription factor is useful to isolate cancer stem cell population.
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