Mechanism for sensing protease allergens by basophils

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659096
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Shinshu University
• Principal Investigator: TAKI Shinsuke 信州大学, 医学系研究科, 教授 (50262027)
• Co-Investigator(Renkei-kenkyūsha): HIDA Shigeaki 信州大学, 医学系研究科, 准教授 (10345762)
• Project Period (FY): 2010 – 2011
• Keywords: アレルギー / サイトカイン / 好塩基球

Research Abstract

Intracellular signal transduction through putative' sensor' for the allergen papain on murine basophils leading to IL-4 production was studied. IFcεRIβ-deficient basophils unable to display FcεRI on their cell surface mounted only around 50% magnitude of papain responses compared with those in wild-type basophils, indicating that FcεRI constitutes a fraction of papain sensors, while other, as yet unidentified, surface molecules could serve as papain sensors.

Research Products

• [Journal Article] IRF-2 regulates B cell proliferation and antibody production through distinct mechanisms (2012)
  • Author(s): Minamoto K, Takahara K, Adachi T, Nagaoka K, Iyoda T, Taki S, Inaba K
  • Journal Title: Int Immunol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Differential requirements for IFN regulatory factor-2 in generation of CD1d-independent T cells bearing NK cell receptors (2012)
  • Author(s): Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S
  • Journal Title: J. Immunol Volume: 188 Pages: 4838-4845
  • DOI: DOI:10.4049/jimmunol.1200210
  • Peer Reviewed
• [Journal Article] IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/-mice (2011)
  • Author(s): Yoshizawa K, Nakajima S, Notake S, Miyagawa S, Hida S, Taki, S
  • Journal Title: J. Immunol Volume: 187 Pages: 5162-5169
  • DOI: DOI:10.4049/jimmunol.1101561
  • Peer Reviewed
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res Volume: 90 Pages: 362-372
  • DOI: DOI:10.1093/cvr/cvq397
  • Peer Reviewed
• [Journal Article] 活性化T細胞におけるNKレセプターの発現 (2011)
  • Author(s): 野竹剛、瀧伸介
  • Journal Title: 臨床免疫・アレルギー科 Volume: 55 Pages: 475-482
• [Journal Article] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling (2010)
  • Author(s): Yamazaki K, Yamazaki T, Taki S, Miyake K, Hayashi T, Ochs HD, Agematsu K
  • Journal Title: J. Clin. Immunol Volume: 135 Pages: 125-136
  • DOI: DOI:10.1016/j.clim.2009.12.013
  • Peer Reviewed
• [Journal Article] 好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化 (2010)
  • Author(s): 小田朗永、瀧伸介
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 546-553
• [Journal Article] Th2分化と好塩基球 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 実験医学 Volume: 28 Pages: 1879-1884
• [Journal Article] 好塩基球からのIL-4産生誘導機序 (2010)
  • Author(s): 肥田重明、瀧伸介
  • Journal Title: 炎症と免疫 Volume: 18 Pages: 9-13
• [Presentation] 好塩基球におけるサイトカイン・シグナルの正と負の制御 (2012)
  • Author(s): 瀧伸介
  • Organizer: 第117回日本解剖学会総会,リンパ系・免疫系懇話会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-26
• [Presentation] IL-3-induced IL-13 production by basophils but not mast cells was sensitive to Paired immunoglobulin-like receptor(PIR)-B mediated inhibitory signals (2011)
  • Author(s): A. Oda, Y. Sakamoto, H. Sanjo, T. Notake, T. Takai, S. Hida, S. Taki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] IL-15-independent generation of memory-like' innate' CD8+ T cells in IRF-2-deficient mice (2011)
  • Author(s): T. Notake, A. Oda, H. Sanjo, S. Hida, S. Taki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Paired immunoglobulin-like receptor(PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils (2010)
  • Author(s): A. Oda, Y. Sakamoto, T. Takai, S. Hida, S. Taki
  • Organizer: 14th international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-27
• [Presentation] Generation of CD1d-independent T cells bearing various NK receptors requires interferon regulatory factor-2 differentially (2010)
  • Author(s): T. Notake, S. Horisawa, F. Arakura, S. Hida, S. Taki
  • Organizer: 14th international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-25
• [Presentation] Regulation of B cell function and development through IRF-2 in type I interferon receptor-dependent and-independent mechanisms (2010)
  • Author(s): K. Minamino, T. Adachi, K. Nagaoka, K. Takahara, S. Taki, K. Inaba
  • Organizer: 14th international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-24
• [Presentation] Basophils sense various external signals with their FcRγ-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses (2010)
  • Author(s): S. Hida, A. Oda, I. Koshi, S. Taki
  • Organizer: 14th international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling (2010)
  • Author(s): K. Yamazaki, T Hayashi, S. Taki, K. Miyake, H. D. Ochs, K. Agematsu
  • Organizer: 14th international congress of immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm