2012 Fiscal Year Final Research Report
Newly development of liposomes vaccines using influenza virus andT cell epitope peptide derived from Japanese cedar pollen
Project/Area Number |
22659121
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Hygiene
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
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Project Period (FY) |
2010 – 2012
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Keywords | インフルエンザ / スギ花粉症 / T細胞エピトープ / リポソームワクチン / ペプチドワクチン / α-GalCer / 細胞傷害性Tリンパ球 / 細胞傷害性Tリンパ球 |
Research Abstract |
We constructed liposomes vaccines, in α-GalCe, an activated substance in NKT cell was inserted into the bilayers of phospholipid liposome capsules, and T cell epitopes derived from Japanese cedar pollen was included and attached to the surface of CTL epitopes. We examined IFV titers in the model mouse infected by influenza virus and sensitized by Japanese cedar pollen. In results, the administration of the vaccines for 6 days before the infection showed the prophylactic effects.
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Research Products
(53 results)
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[Journal Article] Epidemiological study on the involvements of environmental factors and allergy in child mental health using autism spectrum questionnaire.2013
Author(s)
Shibata A, Hitomi Y, Kambayashi Y, Hibino Y, Yamazaki M, Mitoma J, Asakura H, Hayashi K, Otaki N, Sagara T, Nakamura H
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Journal Title
Res Autism Spectr Disord.
Volume: 7
Pages: 132-140
DOI
Peer Reviewed
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[Journal Article] Decreased activity of daily living produced by the combination of Alzheimer's disease and lower limb fracture in elderly requiring nursing care2013
Author(s)
Inagawa T, Hamagishi T, Takaso Y, Hitomi Y, Kambayashi Y, Hibino Y, Shibata A, Ngoc NT, Okochi J, Hatta K, Takamuku K, Konoshita T, Nakamura H
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Journal Title
Environ Health Prev Med.
Volume: 18
Pages: 16-23
DOI
Peer Reviewed
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[Journal Article] Cellular Heat Acclimation Regulates Cell Growth, Cell Morphology, Mitogen-activated Protein Kinase Activation, and Expression of Aquaporins in Mouse Fibroblast Cells2012
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H
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Journal Title
Cell Physiol Biochem
Volume: 30
Pages: 450-457
DOI
Peer Reviewed
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[Journal Article] or the JAST study group: A comparison between augmentation with olanzapine and increased risperidone dose in acute schizophrenia patients showing early non-response to risperidone2012
Author(s)
Hatta K, Otachi T, Sudo Y, Kuga H, Takebayashi H, Hayashi H, Ishii R, Kasuya M, Hayakawa T, Morikawa F, Hata K, Nakamura M, Usui C, Nakamura H, Hirata T, Sawa Y
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Journal Title
Psychiatry Res
Volume: 198
Pages: 194-201
DOI
Peer Reviewed
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[Journal Article] Obesity and aspirin intolerance are risk factors for difficult-to-treat asthma in Japanese non-atopic women2012
Author(s)
Fukutomi Y, Taniguchi M, Tsuburai T, Tanimoto H, Oshikata C, Ono E, Sekiya K, Higashi N, Mori A, Hasegawa M, Nakamura H, Akiyama K
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Journal Title
Clin Exp Allergy
Volume: 42
Pages: 738-746
DOI
Peer Reviewed
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, Sugimoto S, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 6
Pages: 57-63
DOI
Peer Reviewed
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[Journal Article] Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy2012
Author(s)
Fukutomi Y, Sjolander S, Nakazawa T, Borres MP, Ishii T, Nakayama S, Tanaka A, Taniguchi M, Saito A, Yasueda H, Nakamura H, Akiyama K
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Journal Title
J Allergy Clin Immunol
Volume: 129
Pages: 860-863
DOI
Peer Reviewed
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[Journal Article] he Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity2012
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Ito K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 40-44
DOI
Peer Reviewed
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[Journal Article] Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo2012
Author(s)
Ngatu NR, Okajima MK, Yokogawa M, Hirota R, Eitoku M, Muzembo BA, Dumavibhat N, Takaishi M, Sano S, Kaneko T, Tanaka T, Nakamura H, Suganuma N
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Journal Title
Ann Allergy Asthma Immunol.
Volume: 108
Pages: 117-122
DOI
Peer Reviewed
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[Journal Article] Association between Body Mass Index and Asthma among Japanese Adults: Risk within the Normal Weight Range2012
Author(s)
Fukutomi Y, Taniguchi M, Nakamura H, Konno S, Nishimura M, Kawagishi Y, Okada C, Tanimoto Y, Takahashi K, Akasawa A, Akiyama K
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Journal Title
Int Arch Allergy Immunol
Volume: 157
Pages: 281-287
DOI
Peer Reviewed
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[Journal Article] Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway2012
Author(s)
Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A
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Journal Title
The Scientific World Journal
Pages: 748572
DOI
Peer Reviewed
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[Journal Article] Time trend in the prevalence of adult asthma in Japan: Findings from population-based surveys in Fujieda City in 1985, 1999, and 20062011
Author(s)
Fukutomi Y, Taniguchi M, Watanabe J, Nakamura H, Komase Y, Ohta K, Akasawa A, Nakagawa T, Miyamoto T, Akiyama K
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Journal Title
Allergol Int
Volume: 60
Pages: 443-448
DOI
Peer Reviewed
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[Journal Article] for the JAST study group.: Difference in early prediction of antipsychotic non-response between risperidone and olanzapine in the treatment of acute-phase schizophrenia2011
Author(s)
Hatta K, Otachi T, Sudo Y, Hayakawa T, Ashizawa Y, Takebayashi H, Hayashi N, Hamakawa H, Ito S, Nakase R, Usui C, Nakamura H, Hirata T, Sawa Y
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Journal Title
Schizophr Res
Volume: 128
Pages: 127-135
DOI
Peer Reviewed
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[Journal Article] C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population2010
Author(s)
Sauriasari R, Sakano N, Wang DH, Takaki J, Takemoto K, Wang B, Sugiyama H, Sato Y, Takigawa T, Takahashi N, Kanbara S,Hitomi Y, Nakamura H, Ogino K
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Journal Title
Hypertens Res
Volume: 33
Pages: 1129-1136
DOI
Peer Reviewed
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[Journal Article] A prospective naturalistic multicentre study of intravenous medications in behavioural emergencies: haloperidol versus flunitrazepam2010
Author(s)
Hatta K, Nakamura M, Yoshida K, Hamakawa H, Wakejima T, Nishimura T, Furuta K, Kawabata T, Hirata T, Usui C, Nakamura H, Sawa Y
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Journal Title
Psychiatry Res.
Volume: 178
Pages: 182-185
DOI
Peer Reviewed
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[Journal Article] Nationwide Cross-Sectional Population-Based Study on the Prevalences of Asthma and Asthma Symptoms among Japanese Adults2010
Author(s)
Fukutomi Y, Nakamura H, Kobayashi F, Taniguchi M, Konno S, Nishimura M, Kawagishi Y, Watanabe J, Komase Y, Akamatsu Y, Okada C, Tanimoto Y, Takahashi K, Kimura T, Eboshida A, Hirota R, Ikei J, Odajima H, Nakagawa T, Akasawa A, Akiyama K:
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Journal Title
Int Arch Allergy Immunol
Volume: 153
Pages: 280-287
DOI
Peer Reviewed
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[Presentation] 児の精神的健康に関連する食行動の疫学研究2012
Author(s)
柴田亜樹,人見嘉哲,神林康弘,日比野由利,朝倉大貴,三苫純子,山崎政美,大滝直人,林宏一,大西孝司,相良多喜子,中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 要介護高齢者におけるアルツハイマー疾患と骨折の合併による生活動作能力の低下2012
Author(s)
稲川利光,濱岸利夫,人見嘉哲,神林康弘,日比野由利,山崎政美,朝倉大貴,三苫純子,柴田亜樹,木戸康人,中村剛,能登裕幸,久保良美,中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 志賀町健康調査における一般住民の疾患とADLの関連2012
Author(s)
山崎政美,人見嘉哲,朝倉大貴,三苫純子,柴田亜樹,神林康弘,日比野由利,四蔵直人,宇野文夫,和田隆志,中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 高齢者における慢性疼痛と日常生活動作(ADL)の低下に関する疫学研究2012
Author(s)
三苫純子,人見嘉哲,朝倉大貴,山崎政美,柴田亜樹,神林康弘,日比野由利,四蔵直人,宇野文夫,和田隆志,中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村 能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 黄砂による慢性咳嗽の症状への影響.2012
Author(s)
東朋美,神林康弘,藤村政樹,吉崎智一,西條清史,早川和一,人見嘉哲,小林史尚,道上義正,中村裕之
Organizer
第82回日本衛生学会学術総会
Place of Presentation
京都大学吉田キャンパス(京都府)
Year and Date
2012-03-25
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[Presentation] アレルギー発症予防フィルターの開発2012
Author(s)
弘田量二,Muzembo Basilua,中村裕之,栄徳勝光,Narongpon Dumavibhat,Ngatu Nlandu Roger,菅沼成文
Organizer
第82回日本衛生学会学術総会
Place of Presentation
京都大学吉田キャンパス(京都府)
Year and Date
2012-03-25
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[Presentation] インターネット調査による本邦の喘息のecological study 有病率の地域差とその規定因子2011
Author(s)
福冨友馬,谷口正実,今野哲,西村正治,大矢幸弘,吉田幸一,岡田千春,高橋清,中村裕之,秋山一男,赤澤晃
Organizer
第51回日本呼吸器学会学術講演会
Place of Presentation
日本呼吸器学会雑誌(誌上開催)
Year and Date
20110300
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