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2012 Fiscal Year Final Research Report

The epidemiological research on the relationship between nitrous acid concentrations in indoor and outdoor and asthma symptoms

Research Project

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Project/Area Number 22659134
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionOsaka Prefectural Institute of Public Health

Principal Investigator

OHYAMA Masayuki  大阪府立公衆衛生研究所, 衛生化学部, 主任研究員 (40175253)

Co-Investigator(Kenkyū-buntansha) TAKENAKA Norimichi  大阪府立大学, 工学(系)研究科(研究院) (70236488)
NAKAJIMA Takae  大阪府立公衆衛生研究所, 衛生化学部, 主任研究員 (70250339)
Project Period (FY) 2010 – 2012
Keywords疫学 / 喘息 / 亜硝酸 / 二酸化窒素 / オゾン / 大気汚染
Research Abstract

Five childhood asthma provided daily information on respiratory symptoms and weekly samplers of indoor HONO, NO_2 and O_3 during about three months from September in investigated each year. In the results, a significant difference was not observed in the relationship between NO_2 and asthmatic attack by Mann-Whitney U test. However, a significant difference was observed in the relationship between HONO and asthmatic attack by Mann-Whitney U test (P=0.0013). Moreover, a significant difference was observed in the relationship between HONO and asthmatic attack by multivariate statistics using environment measurement station data. These results suggested that HONO is more correlated with asthmatic attack than NO_2.

  • Research Products

    (16 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Possible Link between Nitrous Acid and Asthma Induced by Fine Particles2012

    • Author(s)
      Masayuki Ohyama, Norimichi Takenaka, Hiroshi Bandow
    • Journal Title

      Journal of Clinical Toxicology

      Volume: Vol. 2

    • DOI

      doi:.org/10.4172/2161-0495.1000e107

    • Peer Reviewed
  • [Journal Article] Effects of Atmospheric Particles and Several Model Particles of Particulate Matter Components on Human Monocyte-Derived Macrophage Oxidative Responses2012

    • Author(s)
      M. Ohyama, S. Akasaka, T. Otake, K. Morinaga, Y. W. Kim, K.-W. Moon, T. Kameda, S. Adachi
    • Journal Title

      Journal of Clinical Toxicology

      Volume: Vol. 2

    • DOI

      doi:.org/10.4172/2161 -0495.1000121

    • Peer Reviewed
  • [Journal Article] Should the Regulation of Nitrogen Dioxide be Amended for the Regulation of Nitrous Acid?2012

    • Author(s)
      Masayuki Ohyama
    • Journal Title

      Journal of Clinical Toxicology

      Volume: Vol. 2

    • DOI

      doi:.org/10.4172/2161-0495.1000 e103

    • Peer Reviewed
  • [Journal Article] Histological Effect of Nitrous Acid with Secondary Products of NitrogenDioxide and Nitric Oxide Exposure on Pulmonary Tissue in Mice2011

    • Author(s)
      Masayuki Ohyama, Kenji Oka, Shuichi Adachi, Norimichi Takenaka
    • Journal Title

      Journal of Clinical Toxicology

      Volume: Vol. 1

    • DOI

      doi:.org/10.4172/2161 -0494.1000103

    • Peer Reviewed
  • [Journal Article] Effects of nitrous acid exposure on pulmonary tissues in guinea pigs2010

    • Author(s)
      Masayuki Ohyama, Kenji Oka, Shuichi Adachi, Norimichi Takenaka
    • Journal Title

      Inhalation Toxicology

      Volume: Vol. 22 Pages: 930-936

    • Peer Reviewed
  • [Presentation] 大阪とソウルに飛来した黄砂に対するマクロファージの活性酸素反応2013

    • Author(s)
      大山正幸
    • Organizer
      黄砂に関する共同研究会(招待講演)
    • Place of Presentation
      大阪
    • Year and Date
      2013-03-07
  • [Presentation] 大阪と韓国に飛来した黄砂に対するマクロファージの活性酸素反応2012

    • Author(s)
      大山正幸
    • Organizer
      平成24年度日本薬剤師会試験検査センター技術研修会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2012-12-07
  • [Presentation] 亜硝酸と喘息症状の関連性に関する疫学的事例調査2012

    • Author(s)
      大山正幸
    • Organizer
      第53回大気環境学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-09-12
  • [Presentation] 環境中亜硝酸の生体影響を考える2012

    • Author(s)
      大山正幸
    • Organizer
      大気環境学会、近畿支部、人体影響部会(招待講演)
    • Place of Presentation
      大阪
    • Year and Date
      2012-03-13
  • [Presentation] モルモット肺組織に対する亜硝酸曝露の影響-透過型電子顕微鏡による量-反応関係の観察-2011

    • Author(s)
      大山正幸
    • Organizer
      第52回大気環境学会
    • Place of Presentation
      長崎
    • Year and Date
      2011-09-15
  • [Presentation] 黄砂に対するマクロファージの活性酸素反応2011

    • Author(s)
      大山正幸
    • Organizer
      第52回大気環境学会
    • Place of Presentation
      長崎
    • Year and Date
      2011-09-15
  • [Presentation] パッシブサンプラーによる亜硝酸の測定2011

    • Author(s)
      永田真,平野慎悟,竹中規訓,大山正幸,定永靖宗,坂東博
    • Organizer
      第52回大気環境学会
    • Place of Presentation
      長崎
    • Year and Date
      2011-09-15
  • [Presentation] モルモット肺組織に対する亜硝酸曝露の影響-光学顕微鏡と電子顕微鏡による量-反応関係の観察-2010

    • Author(s)
      大山正幸
    • Organizer
      第51回大気環境学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-10
  • [Presentation] 亜硝酸パッシブサンプラーの開発2010

    • Author(s)
      永田真、平野慎悟、竹中規訓、大山正幸、岡憲司、定永靖宗、坂東博
    • Organizer
      第51回大気環境学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-09
  • [Remarks]

    • URL

      http://www.iph.pref.osaka.jp/news/vol43/news43_2.html

  • [Remarks]

    • URL

      http://www.iph.pref.osaka.jp/merumaga/back/104-2.html

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Published: 2014-08-29   Modified: 2015-01-14  

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