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2011 Fiscal Year Final Research Report

Search for protein expression in amphetamines treated mouse heart : Challenge to the diagnosis for the sudden death of amphetamines abusers

Research Project

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Project/Area Number 22659138
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionFukuoka University

Principal Investigator

KUBO Shin-ichi  福岡大学, 医学部, 教授 (10205122)

Co-Investigator(Kenkyū-buntansha) IKEMATSU Kazuya  長崎大学, 医歯薬学総合研究科, 准教授 (80332857)
ABE Syuntarou  大阪医科大学, 医学部, 助教 (80335116)
Project Period (FY) 2010 – 2011
Keywords法医学 / 覚醒剤 / 心臓突然死 / 心肥大 / 致死性不整脈
Research Abstract

In this study, the pathological changes of cardiac region, especially impulse conducting system in amphetamines(MA)-abusers was investigated. In long term MA-treated mouse-model, cardiac tissue was examined by 2-dementional electrophoresis to observe the changes of protein expressions. After long-term 0MA treatment, mTOR passway, related to program cell death(PCD) was activated. Gene expressions of potassium-channel associated genes were down regulated in MA-treated mouse. MA might change the action potential of cardiac cells to induce the cardiac sudden death.

  • Research Products

    (2 results)

All 2011 2010

All Presentation (2 results)

  • [Presentation] メタンフェタミン投与マウスの心臓におけるカリウムチャンネル関連遺伝子の発現2011

    • Author(s)
      松尾綾、池松和哉、中園一郎
    • Organizer
      日本法中毒学会第30年会
    • Place of Presentation
      長崎市
    • Year and Date
      2011-06-10
  • [Presentation] メタンフェタミン投与マウスの心臓におけるPhosphoinositide 3-kinase経路関連遺伝子の発現動態2010

    • Author(s)
      松尾綾、池松和哉、久保真一、中園一郎
    • Organizer
      第94次日本法医学会学術全国集会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-25

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Published: 2013-07-31  

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