2012 Fiscal Year Final Research Report
Arterial stiffness as an index for systemic aging
| Project/Area Number |
22659143
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
KOHARA Katsuhiko 愛媛大学, 大学院・医学系研究科, 准教授 (30260384)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 老年医学 / 老化指標 |
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| Research Abstract |
The relationships between arterial stiffness and 5 components for systemic aging; cognitive impairment, sarcopenia, osteopenia, imbalance, and orthostatic blood pressure dysregulation were investigated in participants to Ehime University Anti-Aging Doc medical check program. Brachial-ankle pulse wavevelocity (baPWV), an index for arterial stiffness, showed significant associations with all indices for systemic aging. Frailty score calculated as summation of the presence of each component of systemic aging showed a dose-dependent positive association with baPWV. Furthermore, baPWV>1800cm/sec was an independent risk for the presence of 3 or more systemic aging components even after correction for possible confounding parameters (O.R. 2.67). These findings indicate that increase in baPWV could facilitate accumulation of systemic aging components to develop pre-frailty syndrome.
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Research Products
(56 results)
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[Journal Article] Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population2013
Author(s)
Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Kawamoto R, Kohara K, Miki T, Osawa H
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Journal Title
Diabetes
Volume: 62
Pages: 649-652
Peer Reviewed
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[Journal Article] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia2013
Author(s)
Nakayama K, Ogawa A, Miyashita H,Tabara Y, Igase M, Kohara K,Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S
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Journal Title
Hum Genet
Volume: 132
Pages: 201-217
Peer Reviewed
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[Journal Article] Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation2012
Author(s)
Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida SI, Yatsu K, Toya Y, Yasuda G, Kohara K,Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S
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Journal Title
Hypertension
Volume: 59
Pages: 854-860
Peer Reviewed
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[Journal Article] Global Blood Pressure Genetics Consortium, Umemura S, Ueshima H, Miki T. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project2010
Author(s)
Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P
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Journal Title
Hypertension
Volume: 56
Pages: 973-980
Peer Reviewed
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[Journal Article] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population2010
Author(s)
Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H
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Journal Title
J Hum Genet
Volume: 55
Pages: 600-604
Peer Reviewed
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[Journal Article] A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population2010
Author(s)
Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H.
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Journal Title
PLoS One
Volume: 5
Pages: e9718
Peer Reviewed
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[Journal Article] Association of four genetic loci with uric acid levels and reduced renal function: The J-SHIPP Suita study2010
Author(s)
Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T
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Journal Title
Am J Nephrol
Volume: 32
Pages: 279-286
Peer Reviewed
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[Presentation] Thigh Muscle Mass Decline Was Associated Brain Small Vessel Diseases in Men; Possible Link between Sarcopenia and Dementia.2012
Author(s)
Ochi M, Kohara K,Tabara Y, Takita R, Nagai T, Shinohara N, Okada Y, Ochi H, Igase M, Miki T
Organizer
64th American Academy of Neurology Annual Meeting
Place of Presentation
New Orleans, USA.
Year and Date
20120421-28
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[Presentation] Epidemiological Studies Suggest the Link between Sleep Disorders and Nonspecific Headache Including Chronic Headache2012
Author(s)
Nagai T, Kohara K,Tabara Y, Okada Y, Ochi M, Kido T, Uetani E, Kido M, Igase M, Miki T
Organizer
64th American Academy of Neurology Annual Meeting
Place of Presentation
New Orleans, USA
Year and Date
20120421-28
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[Presentation] Relatively Lower Central Aortic Pressure in Subjects with Impaired Insulin Sensitivity and Resistance: The Toon Health Study2011
Author(s)
Tabara Y, Saito I, Nishida W, Kohara K,Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
Organizer
High Blood Pressure Research 2011 Scientific Sessions
Place of Presentation
Orland, USA.
Year and Date
20110920-24
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[Presentation] Increased levels of soluble p3-Alcadeinαin plasma of patients with Alzheimer's disease.2011
Author(s)
Kamogawa K, Kohara K, Tabara Y, Ochi M, Nagai T, Takita R, Igase M, Miki T, Konno T, Hata S, Suzuki T
Organizer
63rd AAN Annual Meeting
Place of Presentation
Honolulu, USA.
Year and Date
20110409-16
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[Presentation] Atherosclerotic indices for the presence of cognitive impairment in a general population: J-SHIPP Study2011
Author(s)
Kohara K,Tabara Y, Ochi M, Nagai T, Okada Y, Kamogawa K, Takita R, Kawano Y, Igase M, Miki T.
Organizer
63rd AAN Annual Meeting
Place of Presentation
Honolulu, USA.
Year and Date
20110409-16
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