2011 Fiscal Year Final Research Report
A novel approach to ALS pathogenesis by investigating conformational equilibrium of TDP-43
| Project/Area Number |
22659171
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
URUSHITANI Makoto 滋賀医科大学, 分子神経科学研究センター, 准教授 (60332326)
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| Co-Investigator(Kenkyū-buntansha) |
KITAHARA Ryo 立命館大学, 薬学部, 准教授 (70512284)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経分子病態学 / TDP-43 |
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| Research Abstract |
TAR DNA-binding protein 43kDa (TDP-43) is implicated in the pathogenesis of amyotrophic lateral sclerosis, the molecular basis of which underlying ALS pathogenesis is yet to be clarified.We have several residues showing irreversible structural change in TDP-43 proteins. Furthermore, antibodies raised against these residues recognized cytoplasmic TDP-43, typical signatures for ALS.
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[Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions.2011
Author(s)
Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto A, Takahashi R, Ito H.
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Journal Title
Neurology
Volume: 77
Pages: 1995-1997
Peer Reviewed
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[Journal Article] Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model.2011
Author(s)
Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R.
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Journal Title
PLoS ONE
Volume: 6
Pages: e20427
Peer Reviewed
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[Journal Article] Induction of protective immunity by vaccination with wild-type apo SOD1 in the mutant SOD1 transgenic mice.2010
Author(s)
Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R, Tooyama I, Taniguchi N, Julien JP, Urushitani M.
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Journal Title
J Neuropathol Exp Neurol.
Volume: 69
Pages: 1044-1056
Peer Reviewed
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[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.2010
Author(s)
Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A, Tooyama I.
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Journal Title
Biomaterials.
Volume: 31
Pages: 4179-4185
Peer Reviewed
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