2012 Fiscal Year Final Research Report
Functional Connectivity Across Cortical Regions in Schizophrenia
| Project/Area Number |
22659210
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Tatsuya 金沢大学, 附属病院, 講師 (10334773)
MURAKAMI Masako 金沢大学, 医学系, 助教 (20324072)
KIKUCHI Mitsuru 金沢大学, 子どものこころ発達研究センター, 特任准教授 (00377384)
UEDA Fumiaki 金沢大学, 附属病院, 講師 (80293356)
SEKIHARA Kensuke 首都大学東京, システムデザイン研究科, 教授 (40326020)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳波 / 脳磁図 |
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| Research Abstract |
Functional connectivities among cerebral cortical areas wereassessed by electroencephalography and magnetoencephalography in patients with schizophrenia. Drug-naive and first-episode patients exhibited reduced synchronizations of neural activities across global cortical areas. This reduction was most prominent betweenfrontal regions and other cortical areas. Amelioration of symptoms by antipsychotics was positively correlated with the improvement of the global synchronizations. Chronic patients, after the long-term treatments, showed increased coherences among cortical areas. Antipsychotic treatment appeared to have an effect to enhance the cortical synchronization.
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