2012 Fiscal Year Final Research Report
Elucidation of the radio-sensitization mechanism by heat
Project/Area Number |
22659224
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Radiation science
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Research Institution | Gunma University |
Principal Investigator |
TAKAHASHI Akihisa 群馬大学, 先端科学研究指導者育成ユニッ ト, 准教授 (60275336)
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Project Period (FY) |
2010 – 2012
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Keywords | 放射線治療 / 温熱治療 / 感受性 / 放射線増感 / DNA二本鎖切断 |
Research Abstract |
We already proposed the formation of DNA double-strand breaks (DSBs) by heat-treatment. Here we found that the HR-deficient cells were sensitive, and were low efficiency of DSB repair by heat when compared to the NHEJ-deficient cells and their parental cells. In addition, we demonstrated that heat-induced DSBs were repaired by HR. Our novel findings suggest that the HR exerts an importantrole in the radio-sensitization mechanism by heat.
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[Journal Article] siRNA targeted for nbs1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011
Author(s)
Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T.
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Journal Title
Int J Hyperthermia
Volume: 27
Pages: 297-304
DOI
Peer Reviewed
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[Journal Article] ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating2010
Author(s)
Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen JD, Ohnishi K, Ohnishi T.
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Journal Title
J Radiat Res (Tokyo)
Volume: 51
Pages: 417-422
DOI
Peer Reviewed
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