2012 Fiscal Year Final Research Report

Molecular imaging for the evaluation of chemosensitivity by a novel hyperpolarized magnetic resonance imaging

Research Project

Project/Area Number	22659226
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	National Cancer Center Japan
Principal Investigator	FUJII Hirofumi 独立行政法人国立がん研究センター, 臨床開発センター, 分野長 (80218982)
Co-Investigator(Kenkyū-buntansha)	YAMAGUCHI Masayuki 独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (90450577) UMEDA O. Izumi 独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40160791)
Project Period (FY)	2010 – 2012
Keywords	核磁気共鳴画像(MRI) / 超偏極 / 分子イメージング
Research Abstract	We investigated the pre-clinical tests for the introduction of NMR-SABRE, a novel hyperpolarized nuclear magnetic resonance technique. One was the evaluation of the safety of hyperpolarized probes. In this study, we searched for safe alternative solvents and catalysts instead of materials that are currently used in basic researches. The other was the development of methods for in vivo prediction of chemosensitivity in animal tumor models. In this study, we suggested the usefulness of the quantification of total choline and diffusion index. The evaluation methods of 5-FU, an anticancer drug, and its cytotoxic metabolite were also studied using NMR technique.