Contribution of the genomic diversity to the development and carcinogenesis of endometriosis

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659302
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Juntendo University
• Principal Investigator: KATO Kiyoko 順天堂大学, 医学研究科, 准教授 (10253527)
• Co-Investigator(Kenkyū-buntansha): KITADE Mari 順天堂大学, 医学部, 准教授 (20266026) ; WAKE Norio 九州大学, 大学院・医学研究科, 教授 (60091584)
• Project Period (FY): 2010 – 2011
• Keywords: 子宮内膜 / 子宮内膜症 / 子宮体癌 / 遺伝子多型 / エストロゲン / p53 / MMDM2

Research Abstract

Tumorigenicity and the ER transcriptional activity were enhanced in endometrial stem cells harboring mutant KRAS compared with that in NSP harboring mutant KRAS gene. The ER/MDM2/p53/p21 pathway play an important role in the occurrence of endometrial cancer. The combination of homozygous GG genotype of MDM2 SNP309 and homozygous Arg/Arg genotype of TP53 codon72 was significantly associated the risk of endometrial cancer.

Research Products

• [Journal Article] Effect of transient TCDD exposure on immortalized human trophoblast-derived cell lines (2011)
  • Author(s): Fukushima K, Tsukimori K, Li D, Takao T, Morokuma S, Kato K, Seki H, Takeda S, MatsumuraS, Wake N
  • Journal Title: Hum Exp Toxicol
  • DOI: doi:10.1177/0960327111424305
  • Peer Reviewed
• [Journal Article] Isolation and Characterization of Human Trophoblast Side-Population(SP) Cells in Primary Villous Cytotrophoblasts and HTR-8/SVneo Cell Line (2011)
  • Author(s): Takao T, Asanoma K, Kato K, Fukushima K, Tsunematsu R, Hirakawa T, Matsumura S, Seki H, Takeda S, Wake N
  • Journal Title: PLoS One Volume: 6 Pages: e21990
  • Peer Reviewed
• [Journal Article] Effects of S-equol and natural S-equol supplement(SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice (2011)
  • Author(s): Onoda A, Ueno T, Uchiyama S, Hayashi SI, Kato K, Wake N
  • Journal Title: Food Chem Toxicol Volume: 49(9) Pages: 2279-2284
  • Peer Reviewed
• [Journal Article] Sodium Butyrate inhibitis the Self-Renewal Capacity of Endometrial Tumor Side-Population Cells by Induction a DNA Damage Response (2011)
  • Author(s): Kato K, Kuhara A, Yoneda T, Inoue T, Takao T, Ohgami T, Dan L, Kuboyama A, Kusunoki S, Takeda S, Wake N
  • Journal Title: Mol Cancer Ther Volume: 10 Pages: 1-10
  • Peer Reviewed
• [Journal Article] 子宮内膜症ダグラス窩深部病変から発生したと考えられる腺癌の一例 (2010)
  • Author(s): 寺尾泰久, 須賀新, 楠木総司, 木村美葵, 荻島大貴, 加藤聖子, 竹田省, 正岡亜希子, 樋野興夫, 福村由紀, 八尾隆史
  • Journal Title: 日本産科婦人科学会関東連合地方部会誌 Volume: 47 Pages: 149-156
  • Peer Reviewed
• [Journal Article] 卵巣子宮内膜症性のう胞摘出後の再発に関する検討 (2010)
  • Author(s): 中村博子、加藤聖子、内田聡子、恒松良祐、礒邉明子
  • Journal Title: 日産婦内視鏡学会雑誌 Volume: 25 Pages: 442-446
  • Peer Reviewed
• [Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events (2010)
  • Author(s): Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K
  • Journal Title: The American Journal of Human Genetics Volume: 86 Pages: 918-928
  • Peer Reviewed
• [Journal Article] Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photodynamic antisense strategy (2010)
  • Author(s): Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photodynamic antisense strategy
  • Journal Title: Oligonucleotides Volume: 20 Pages: 37-44
  • Peer Reviewed
• [Journal Article] Low-dose mithramycin exerts its anti-cancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers (2010)
  • Author(s): Ohgami T, Kato K, Kobayashi H, Sonoda K, Inoue T, Yamaguchi S, Yoneda T, Wake N
  • Journal Title: Cancer Sci Volume: 101 Pages: 1387-1395
  • Peer Reviewed
• [Journal Article] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage (2010)
  • Author(s): Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N
  • Journal Title: Am J Pathol Volume: 176 Pages: 381-392
  • Peer Reviewed
• [Journal Article] Characterization of side-population cells in human normal endometrium and endometrial cancer cells (2010)
  • Author(s): Kato K. and Wake N
  • Journal Title: Curr. Res. in Cancer Volume: 4 Pages: 51-66
• [Presentation] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response (2011)
  • Author(s): Kiyoko Kato
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20111003-05
• [Presentation] 子宮体癌stem-like cellに対するヒストン脱アセチル化酵素阻害剤の効果と作用機序 (2011)
  • Author(s): 加藤聖子、楠木総司、金田容秀、木村美葵、須賀新、寺尾泰久、和氣徳夫、竹田省
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110829-31
• [Presentation] 子宮内膜幹細胞(side population細胞)の発癌機構への関与 (2011)
  • Author(s): 加藤聖子、楠木総司、木村美葵、金田容秀、須賀新、寺尾泰久、和氣徳夫、竹田省
  • Organizer: 第50回日本婦人科腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 20110722-24
• [Presentation] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response (2011)
  • Author(s): Kiyoko Kato, Aya Kuhara, TomokoYoneda, Takafumi Inoue, Tomoka Takao, TatsuhiroOhgami, Li Dan, Ayumi Kuboyama, Soshi Kusunoki, Satoru Takeda, Norio Wake
  • Organizer: 第9回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20110513-14
• [Presentation] 子宮体癌幹細胞の生物学的特性の解析と癌幹細胞を標的とした新規治療法の開発 (2011)
  • Author(s): 加藤聖子
  • Organizer: 第15回バイオ治療法研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-12-03
• [Presentation] Characterization of side population cells in human endometrium and endometrial cancer (2010)
  • Author(s): Kiyoko Kato
  • Organizer: Kaohsiung International Cancer Symposium
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 20101121-22
• [Presentation] 子宮体癌幹細胞における生物学的特性の解析と標的治療開発の試み (2010)
  • Author(s): 加藤聖子
  • Organizer: 第48回日本癌治療学会学術集会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20101028-30
• [Presentation] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage (2010)
  • Author(s): Kiyoko Kato
  • Organizer: The 8^<th> Stem Cell Research Symposium
  • Place of Presentation: Awazi city
  • Year and Date: 20100513-15
• [Book] 婦人科・乳腺外科疾患ビジュアルブック胞状奇胎 (2011)
  • Author(s): 楠木総司、加藤聖子
  • Total Pages: 236-239
  • Publisher: 学研メディカル秀潤社
• [Book] 婦人科・乳腺外科疾患ビジュアルブック絨毛癌,存続絨毛症 (2011)
  • Author(s): 寺尾泰久、加藤聖子
  • Total Pages: 240-244
  • Publisher: 学研メディカル秀潤社