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2012 Fiscal Year Final Research Report

Developing of polymeric micelle for molecular targeting to cancer stem cells in ovarian cancer patients.

Research Project

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Project/Area Number 22659303
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

OHMICHI Masahide  大阪医科大学, 医学部, 教授 (10283764)

Co-Investigator(Kenkyū-buntansha) TERAI Yoshito  大阪医科大学, 医学部, 講師 (90278531)
TANABE Akiko  大阪医科大学, 医学部, 助教 (70454543)
KANEMURA Masanori  大阪医科大学, 医学部, 講師 (40298782)
SASAKI Hiroshi  大阪医科大学, 医学部, 助教 (80432491)
Project Period (FY) 2010 – 2012
KeywordsCD24, 婦人科悪性腫瘍 / 上皮間葉形質転換 / EMT, 高分子ミセル / 抗癌剤耐性
Research Abstract

The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer cells. EMT is an important step in the invasion and metastasis of cancer. G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen receptor that functions alongside traditional estrogen receptors to regulate the cellular responses to estrogen. Current study suggested that the expression of both GPR30 and EGFR is associated with a poor outcome in ovarian cancer, and GPR30 increases the phosphorylation of Akt via the EGFR in ovarian cancer cells. The regulation of GPR30 might be a potentially useful new therapeutic target in ovarian cancer. Furthermore, Recently CD24 has been considered as a prognostic maker in various cancers. So we analyzed the prognostic impact of the CD24 expression in ovarian cancer by immunostaining. The CD24 expression was significantly associated with FIGO stage, lymph node metastasis and peritoneal metastasis. The in vitro examination showedthat high expression level of CD24 is significantly associated with EMT positivity. In addition, the CD24 overexpression increased invasiveness, and knockdown of CD24 suppressed cell invasion. In conclusion CD24 expression in ovarian cancer may be related to tumor invasion and migration. Based on the results, the anti-cancer agent incorporated polymeric micelles, which have anti-GPR30 or anti-CD24 antibodies in their outer layer, are in development

  • Research Products

    (11 results)

All 2013 2012 2010

All Journal Article (2 results) Presentation (9 results)

  • [Journal Article] Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer.2013

    • Author(s)
      anaka Y, Terai Y (分担) , Kawaguchi H, Fujiwara S, Yoo S, Tsunetoh S, Takai M, Kanemura M(分担), Tanabe A(分担), Ohmichi M (代表).
    • Journal Title

      Cancer Biology and Therapy

      Volume: 14(1) Pages: 13-19

  • [Journal Article] GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer.2012

    • Author(s)
      Fujiwara S, Terai Y(分担)、Kawaguchi H, Takai M, Yoo S, Tanaka Y, Tanaka T,Tsunetoh S, Sasaki H (分担)、Kanemura M (分 担)、Tanabe A (分担)、Ohmichi M (代表)
    • Journal Title

      Journal of Ovarian Research

      Volume: 5(1) Pages: 35-44

  • [Presentation] 婦人科癌 の浸潤転移におけるEMT(Epithelial Mesenchymal Transition)の 意義と EMT 制御をターゲットとした新規治療の基礎的研究2012

    • Author(s)
      寺井義人
    • Organizer
      第53回日本婦人科腫瘍学会
    • Place of Presentation
      岡山
    • Year and Date
      2012-11-23
  • [Presentation] 高井雅聡卵巣癌の播種転移は EMT 現象を反映する2012

    • Organizer
      第50回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-25
  • [Presentation] 卵巣癌におけるEMT 現象の指標となる Ecadherin, snail, slug の発現意義2012

    • Author(s)
      高井雅聡
    • Organizer
      第64回日本産婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-01
  • [Presentation] 白金製剤耐性卵巣癌における Akt をターゲットとした分子標的薬としての Gemcitabine の 機能解析2012

    • Author(s)
      川口浩史
    • Organizer
      第64回日本産婦人科学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-01
  • [Presentation] 白金製剤耐性卵巣癌における Akt をターゲットとした分子標的薬としての Gemcitabine の機能解析2012

    • Author(s)
      川口浩史
    • Organizer
      第52回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-19
  • [Presentation] 卵巣癌におけるエストロゲン受容体 GPR30 の上皮間葉転換(EMT)への関与2012

    • Author(s)
      藤原聡枝
    • Organizer
      第52回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-19
  • [Presentation] 卵巣癌における GPR30 の免疫組織学的検討2010

    • Author(s)
      藤原聡枝
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-28
  • [Presentation] 卵巣癌における GPR30 の免疫組織学的検討2010

    • Author(s)
      藤原聡枝
    • Organizer
      第62回日本産婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
  • [Presentation] 卵巣癌における EGFR 遺伝子変異とその下流 シグナル分子の発現解析2010

    • Author(s)
      田中良道
    • Organizer
      第62回日本産婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23

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Published: 2014-08-29  

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