2011 Fiscal Year Final Research Report
Establishment of human iPS cells originated from retinal tissues
| Project/Area Number |
22659316
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
AZUMA Noriyuki 独立行政法人国立成育医療研究センター, 眼科医長・細胞医療研究室長 (10159395)
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Akihiro 独)国立成育医療研究センター(研究所), 生殖細胞医療研究部, 部長 (70213486)
SEKO Yuko 独)国立成育医療研究センター(研究所), 生殖細胞医療研究部, 共同研究員 (60301157)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生医学 / iPS細胞 / 遺伝子・細胞治療 / 網膜 / 遺伝学 |
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| Research Abstract |
We generated human iPS cells from the retinal tissues obtained during surgery. By methylation analysis, the iPS cells have characteristics of stem cells similar to those of ES cells. Neural retina cells and retinal pigmented epithelia are identified in teratoma formation. Thus the iPS cells are useful to from highly differentiated retinal cells for reproducing medicine.
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[Journal Article] Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the Japanese population2012
Author(s)
Hosono K, Ishigami C, Takahash M, Park DH, Hirami Y, Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima S, Hotta Y.
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Journal Title
PLoS ONE
Volume: 7
Pages: e-31036
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[Journal Article] Ophthalmic features of CHARGE syndrome with CHD7 mutations2012
Author(s)
Nishina S, Kosaki R, Yagihashi T, Azuma N, Okamoto N, Hatsukawa Y, Kurosawa K, Yamane T, Mizuno S, Tsuzuki K, Kosaki K.
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Journal Title
Am J Med Genet Part A
Volume: 158A
Pages: 514-518
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[Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex2011
Author(s)
Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H.
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Journal Title
J Neurosci
Volume: 31(46)
Pages: 16872-16883
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[Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex2011
Author(s)
Yamasaki1 T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H.
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Journal Title
Journal of Neuroscience
Volume: 31
Pages: 16872-16883
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[Journal Article] Heterozygous OTX2 mutations are associated with variable pituitary phenotype2010
Author(s)
Dateki S, Kosaka K, Hasegawa K, Tanaka H, Azuma N, Yokoya S, Muroya K, Adachi M, Tajima T, Motomura K, Kinoshita E, Moriuchi H, Fukami M, Ogata T.
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Journal Title
J Clin Endocrinol Metab
Volume: 95
Pages: 756-764
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[Journal Article] p38mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating MEF2C-dependent BMP2 transcription2010
Author(s)
Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H.
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Journal Title
Stem Cells Dev
Volume: 19
Pages: 1723-1734
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[Presentation] 永本敏之,東範行,不二門尚,石橋達朗,佐藤美保,近藤峰生,大鹿哲郎,黒坂大次郎2011
Author(s)
永本敏之,東範行,不二門尚,石橋達朗,佐藤美保,近藤峰生,大鹿哲郎,黒坂大次郎
Organizer
第65回日本臨床眼科学会
Year and Date
20111000
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