2012 Fiscal Year Final Research Report
The role of epithelial-mesenchymal transition in metastasis and progression of pediatric solid tumors.
| Project/Area Number |
22659317
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | The University of Tokyo (2011-2012)
University of Tsukuba (2010) |
|---|
Principal Investigator |
KOMURO Hiroaki 東京大学, 医学部附属病院, 准教授 (80296128)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 上皮間葉移行 / 小児固形腫瘍 / 神経芽腫 / 遺伝子発現 / 浸潤転移 / 予後 / MYCN |
|---|
| Research Abstract |
The epithelial to mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. We investigated the role of EMT in the progression of Neuroblastoma (NB). Downregulation of KRT19 was highly associated with tumor progression in NB as well as metastasis in localized primary NB. Low expression of ERBB3 was also associated with progression of NB. Expression levels of EMT-related genes might become new promising prognostic markers for neuroblastoma.
|
