2012 Fiscal Year Final Research Report
Development of fetal treatment for severe hypoplastic lung with congenital diaphragmatic hernia
| Project/Area Number |
22659318
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FURUKAWA Taizo 京都府立医科大学, 医学研究科, 助教 (20515291)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Osamu 京都府立医科大学, 医学研究科, 准教授 (10315963)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 先天性横隔膜ヘルニア / ニトロフェン / ボンベシン / 肺低形成 |
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| Research Abstract |
We investigated whether bombesin,which is neuropeptide, has an effect on pulmonary maturity of CDH rat. Pregnant Sprague-Dawley (SD) rat(term22) received 100mg of nitrofen into stomach through nasogastric tube on day 9.5. Lung tissues of CDH rat represented narrowing of alveolar space, hypertrophy of alveolar wall consistent with hypoplastic lung. Lung weight to body weight ratio(LW/BW) was significantly higher in normal group than in CDH group(p
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Research Products
(2 results)
