2012 Fiscal Year Final Research Report
Involvement of Oral Mucosal Immune System in Sublingual Immunotherapy
| Project/Area Number |
22659340
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
AZUMA Miyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHNO Tatsukuni 東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (80435635)
KAMIMURA Yousuke 東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (40549929)
OKANO Mitsuhiro 岡山大学, 医歯薬学総合研究科, 准教授 (60304359)
HASE Hidenori 東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (70332997)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 歯学 / 免疫学 / 口腔粘膜 / 舌下免疫療法 / 樹状細胞 |
|---|
| Research Abstract |
In the studies using hapten fluorescein isothiocyanate (FITC) and protein antigen (Ag) ovalbumin (OVA), we demonstrated that distribution of resident dendritic cells (DCs) in the sublingual mucosa was very limited, and albeit the rapid recruitment of new DCs after non-infectious Ag application, most DCs were disappeared at24 hrs after topical Ag application. The repeated Ag application onto the sublingual mucosa induced altered recruitment of CD11b+ DCs/Macrophages that are distinct from resident DCs. The above observation was confirmed in the sublingual mucosa after sublingual immunotherapy in our newly established cedar pollen rhinitis mouse model without the use of adjuvant and purified cedar pollen extract. Our results suggest that recruitment of unique CD11b+ cells contribute to tolerant mechanisms in sublingual immunotherapy.
|
