2011 Fiscal Year Final Research Report

The new paradigm to search the bioscientific mechanism of malocclusion

Research Project

Project/Area Number	22659375
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Okayama University
Principal Investigator	YAMASHIRO Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70294428)
Co-Investigator(Kenkyū-buntansha)	NAKAGAWA Ichiro 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70294113) YANAGITA Takeshi 岡山大学, 岡山大学病院, 助教 (90534793)
Project Period (FY)	2010 – 2011
Keywords	不正咬合 / エピジェネティクス / 分子機構 / 実験的歯の移動モデル
Research Abstract	In first year of this program, we intended to make a model mouse of malocclusion with feeding different food in hardness. In one side, mice were fed hard solid food, and in the other side, mice were fed powdery food. These mice were grown in same condition for 8weeks, then we analyzed the head of these mice with orthodontic analyze method. In this result, we found out clear difference between two groups. Now we are looking for the bioscientific mechanism of making such a difference.