2012 Fiscal Year Final Research Report
Investigation and physiological analysis of the quantity control factor of mitochondrial DNA
| Project/Area Number |
22680035
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
|---|
Principal Investigator |
SHITARA Hiroshi 公益財団法人東京都医学総合研究所, 基盤技術研究センター, 基盤技術研究職員 (90321885)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 遺伝学 / ミトコンドリア / ミトコンドリアDNA / ミトコンドリアDNA量 |
|---|
| Research Abstract |
Mitochondrial DNA (mtDNA) in mammalian cells exists as multiple copies, which are regulated by various genetic and environmental factors. In this study, we analyzed the regulatory effect of mitochondrial transcription factor A (Tfam) and observed that its overexpression improves the symptoms of mitochondrial deficiency in a mouse model.
|
