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2012 Fiscal Year Final Research Report

Vascularization of three-dimensional complex liver tissues byregulation of interstitial flow

Research Project

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Project/Area Number 22680037
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKeio University

Principal Investigator

SUDO Ryo  慶應義塾大学, 理工学部, 准教授 (20407141)

Project Period (FY) 2010 – 2012
Keywordsマイクロ流体デバイス / 肝臓 / 血管
Research Abstract

There is a demand to reconstruct three-dimensional (3D) complex organs inrecent regenerative medicine. In particular, it is important to reconstruct 3D complex tissues includingmicrovascular networks. In this study, we investigated a technology to vascula

  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] Microfluidic assay for simultaneous cultureof multiple cell types on surfaces or withinhydrogels2012

    • Author(s)
      Yoojin Shin, Sewoon Han, Jessie S. Jeon,Kyoko Yamamoto, Ioannis K. Zervantonakis,Ryo Sudo, Roger D. Kamm, Seok Chung
    • Journal Title

      Nature Protocols

      Volume: 7 Pages: 1247-1259

    • Peer Reviewed
  • [Journal Article] Spatio-temporal control of hepatic stellatecell-endothelial cell interactions forreconstruction of liver sinusoids in vitro2012

    • Author(s)
      Junichi Kasuya, Ryo Sudo, Toshihiro Mitaka,Mariko Ikeda, Kazuo Tanishita
    • Journal Title

      Tissue Engineering Part A

      Volume: 18 Pages: 1045-1056

    • Peer Reviewed
  • [Journal Article] The stabilization effectof mesenchymal stem cells on the formationof microvascular networks in a microfluidicdevice.

    • Author(s)
      Kyoko Yamamoto, Kohei Tanimura, YoMabuchi, Yumi Matsuzaki, Seok Chung,Roger D. Kamm, Mariko Ikeda, KazuoTanishita, Ryo Sudo
    • Journal Title

      Journal of Biomechanical Scienceand Engineering

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Steady and pulsatile shearstress induce differenct three-dimensionalendothelial networks through pseudopodiumformation

    • Author(s)
      Yoshinori Abe, Ryo Sudo, Mariko Ikeda,Kazuo Tanishita.
    • Journal Title

      Journal of Biorheology

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Reconstruction of hepatic stellatecell-incorporated liver capillary structures in small hepatocyte tri-culture usingmicroporous membranes

    • Author(s)
      Junichi Kasuya, Ryo Sudo, Genta Masuda,Toshihiro Mitaka, Mariko Ikeda, KazuoTanishita
    • Journal Title

      Journal of TissueEngineering and Regenerative Medicine

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] A three-dimensional microfluidic tumor cellmigration assay to screen the effect ofanti-migratory drugs and interstitial flow

    • Author(s)
      Johann Kalchman, Shingo Fujioka, SeokChung, Yamato Kikkawa, Toshihiro Mitaka,Roger D. Kamm, Kazuo Tanishita, Ryo Sudo
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] 安定化毛細血管の再生における血管内皮細胞と間葉系幹細胞の相互作用2013

    • Author(s)
      山本 興子
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2013-03-23
  • [Presentation] 血管内皮細胞と間葉系幹細胞の相互作用による毛細血管安定化の検討2013

    • Author(s)
      山本 興子
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      茨城
    • Year and Date
      2013-01-10
  • [Presentation] マウス背側皮膚窓による培養小型肝細胞組織移植に伴う血管新生の観察2013

    • Author(s)
      若杉 美樹
    • Organizer
      日本機械学会第25回バイオエンジニアリング講演会
    • Place of Presentation
      茨城
    • Year and Date
      2013-01-10
  • [Presentation] 生体工学的手法による微小血管構築制御2013

    • Author(s)
      須藤 亮
    • Organizer
      日本機械学会 第25回 バイオエンジニアリング講演会
    • Place of Presentation
      茨城
    • Year and Date
      2013-01-09
  • [Presentation] Three-dimensional liver cancercell migration assay under interstitial flow ina microfluidic system2012

    • Author(s)
      Ryo Sudo
    • Organizer
      1^<st>Annual IEEEEMBS Micro and Nanotechnology inMedicine Conference
    • Place of Presentation
      Ka'anapali, USA
    • Year and Date
      2012-12-04
  • [Presentation] 血管内皮細胞の 3 次元ネットワーク形成に及ぼす間質流の影響2012

    • Author(s)
      阿部順紀
    • Organizer
      日本生体医工学会関東支部若手研究者発表会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-17
  • [Presentation] マウス背側皮膚窓への培養肝細胞組織移植による血管新生観察と組織酸素分圧測定2012

    • Author(s)
      若杉 美樹
    • Organizer
      第16回 酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-29
  • [Presentation] Construction of functionalex-vivo liver tissues withpericytes-incorporated microvessels usingmicroporous membranes2012

    • Author(s)
      Junichi Kasuya
    • Organizer
      3^<rd>TERMIS WorldCongress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2012-09-07
  • [Presentation] Quantitative analysis ofinteractions between capillary networks andhepatocyte tissues in a microfluidic platform2012

    • Author(s)
      Ryo Sudo
    • Organizer
      3^<rd>TERMIS WorldCongress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2012-09-07
  • [Presentation] 小型肝細胞-星細胞-血管内皮細胞共培養モデルにおける肝類洞様構造の再構築と肝細胞機能発現2012

    • Author(s)
      須藤 亮
    • Organizer
      第19回 肝細胞研究会
    • Place of Presentation
      北海道
    • Year and Date
      2012-06-30
  • [Presentation] 肝細胞との共培養が血管内皮細胞の三次元ネットワーク形成に与える影響2012

    • Author(s)
      須藤 亮
    • Place of Presentation
      神奈川
    • Year and Date
      2012-06-12
  • [Presentation] 生体外における肝臓再生への工学的アプローチ2012

    • Author(s)
      須藤 亮
    • Organizer
      分野横断型医工学研究プラットフォーム BASIC 特別講演会
    • Place of Presentation
      宮城
    • Year and Date
      2012-02-29
  • [Presentation] マイクロ流体デバイスを用いた三次元組織再生への工学的アプローチ2012

    • Author(s)
      須藤 亮
    • Organizer
      バイオフィジオロジー研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-02-25
  • [Presentation] Microfluidic culture models forinvestigating normal and cancer cellbehaviors2012

    • Author(s)
      Ryo Sudo
    • Organizer
      バイオメカニクス懇話会
    • Place of Presentation
      北海道
    • Year and Date
      2012-01-16
  • [Presentation] Quantitative analysis of theinteractions between 3D hepatocyte tissueand capillary networks in a microfluidicplatform2011

    • Author(s)
      Tomohiro Tsuji
    • Organizer
      MicroTAS 2011
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-10-03
  • [Presentation] A bioengineering approach toliver tissue engineering2010

    • Author(s)
      Ryo Sudo
    • Organizer
      BiofrontierSymposium 2010
    • Place of Presentation
      石川
    • Year and Date
      2010-11-11
  • [Presentation] Hepatocyte-endothelial cellinteractions monitored in a microfluidicdevice2010

    • Author(s)
      Ryo Sudo
    • Organizer
      World Congress of Biomechanics2010
    • Place of Presentation
      Suntec ConventionCentre, Singapore
    • Year and Date
      2010-08-01
  • [Remarks]

    • URL

      http://www.sudo.sd.keio.ac.jp

URL: 

Published: 2014-08-29  

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