Molecular mechanisms of sarcopenia and nutritional/exercise intervention

2012 Fiscal Year Final Research Report

• Project/Area Number: 22680050
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Ritsumeikan University
• Principal Investigator: FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863)
• Project Period (FY): 2010 – 2012
• Keywords: スポーツ生理学

Research Abstract

The purpose of the study was to examine the effect of resistance exercise in combinationwith essential amino acids intake on the muscle anabolic response. Acute bout ofresistance exercise increased the activity of mTOR signaling pathway in both young andolder subjects. Exercise training using the same exercise protocol induced significantincreases in muscle mass and strength. Furthermore, an acute bout of resistance exercisein combination with essential amino acids additively increased the activity of mTORsignaling pathway.

Research Products

• [Journal Article] Ishii, N. mTOR signaling response toresistance exercise is altered by chronicresistance training and detraining inskeletal muscle (2013)
  • Author(s): Ogasawara, R., Kobayashi, K., Tsutaki,A., Lee, K., Abe, T., Fujita, S., Nakazato, K.
  • Journal Title: J Appl Physiol Volume: 114(7) Pages: 934-40
  • DOI: doi: 10.1152/japplphysiol.01161.2012
  • Peer Reviewed
• [Journal Article] Pulsatile Portal VeinInsulin Delivery Enhances Hepatic InsulinAction and Signaling (2012)
  • Author(s): Matveyenko, A.V., Liuwantara, D., Gurlo,T., Kirakossian, D., Dalla Man, C., Cobelli,C., White, M.F., Copps, K.D., Volpi, E.,Fujita, S., Butler, P.C
  • Journal Title: Diabetes Volume: 61(9) Pages: 2269-79
  • DOI: doi: 10.2337/db11-1462
  • Peer Reviewed
• [Journal Article] Glycerophosphocholine enhancesgrowth hormone secretion and fatoxidation in young adults (2012)
  • Author(s): Kawamura, T., Okubo, T., Sato, K.,Fujita, S., Goto, K., Hamaoka, T., Iemitsu,M
  • Journal Title: Nutrition Volume: 28(11-12) Pages: 1122-6
  • Peer Reviewed
• [Journal Article] DHEA administration and exercise trainingimproves insulin resistance in obese rats (2012)
  • Author(s): Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Ajisaka, R., Fujita, S
  • Journal Title: Nutr Metab (Lond) Volume: 9 Pages: 47
  • Peer Reviewed
• [Journal Article] Supplementation with a flavanol-richlychee fruit extract influences theinflammatory status of young athletes (2011)
  • Author(s): Nishizawa, M., Hara, T., Miura, T.,Fujita, S., Yoshigai, E., Ue, H., Hayashi, Y.,Kwon, A.H., Okumura, T., Isaka, T
  • Journal Title: Phytother Res Volume: 25(10) Pages: 1486-93
  • Peer Reviewed
• [Journal Article] Increased musculardehydroepiandrosterone levels areassociated with improved hyperglycemia inobese rats (2011)
  • Author(s): Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Fujita, S
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 301(2) Pages: 274-80
  • Peer Reviewed
• [Journal Article] Insilico study on the substrate bindingmanner in human myo-inositolmonophosphatase 2 (2011)
  • Author(s): Fujita, S., Ohnishi, T., Okuda, S.,Kobayashi, R., Fukuno, S., Furuta, D.,Kikuchi, T., Yoshikawa, T., Fujita, N
  • Journal Title: J Mol Model Volume: 17(10) Pages: 2559-67
  • Peer Reviewed
• [Journal Article] Increases in thighmuscle volume and strength by walktraining with leg blood flow reduction inolder participants (2011)
  • Author(s): Ozaki, H., Sakamaki, M., Yasuda, T.,Fujita, S., Ogasawara, R., Sugaya, M.,Nakajima, T., Abe, T
  • Journal Title: J Gerontol A Biol SciMed Sci Volume: 66(3) Pages: 257-63
  • Peer Reviewed
• [Journal Article] Pharmacological vasodilation improvesinsulin-stimulated muscle proteinanabolism but not glucose utilization inolder adults (2010)
  • Author(s): Timmerman, K.L., Lee, J.L., Fujita, S.,Dhanani, S., Dreyer, H.C., Fry, C.S.,Drummond, M.J., Sheffield-Moore, M.,Rasmussen, B.B., and Volpi, E
  • Journal Title: Diabetes Volume: 59(11) Pages: 2764-71
  • Peer Reviewed
• [Journal Article] Effects of low-intensitybench press training with restricted armmuscle blood flow on chest musclehypertrophy: a pilot study (2010)
  • Author(s): Yasuda, T., Fujita, S., Ogasawara, R.,Sato, Y., Abe, T
  • Journal Title: Clin PhysiolFunct Imaging Volume: 30(5) Pages: 338-43
  • Peer Reviewed
• [Journal Article] Blood flow restriction exercise stimulatesmTORC1 signaling and muscle proteinsynthesis in older men (2010)
  • Author(s): Fry, C.S., Glynn, E.L., Drummond, M.J., Timmerman, K.L., Fujita, S., Abe, T.,Dhanani, S., Volpi, E., Rasmussen, B.B
  • Journal Title: J Appl Physiol Volume: 108(5) Pages: 1199-209
  • Peer Reviewed
• [Journal Article] Resistance exerciseincreases leg muscle protein synthesis and mTOR signalling independent of sex (2010)
  • Author(s): Dreyer, H.C., Fujita, S., Glynn, E.L.,Drummond, M.J., Volpi, E., andRasmussen, B.B
  • Journal Title: ActaPhysiol Volume: 199(1) Pages: 71-81
  • Peer Reviewed
• [Journal Article] Venous bloodgas and metabolite response tolow-intensity muscle contractions withexternal limb compression (2010)
  • Author(s): Yasuda, T., Abe, T., Brechue, W.F., Iida, H., Takano, H., Meguro, K., Kurano, M.,Fujita, S., and Nakajima, T
  • Journal Title: Metabolism Volume: 59(10) Pages: 1510-9
  • Peer Reviewed
• [Presentation] 運動トレーニングによる性ステロイドホルモン増加は2型糖尿病モデルラットの骨格筋糖代謝を亢進させる. (2012)
  • Author(s): 佐藤幸治、藤田聡、山内秀樹、北村裕美、代谷陽子、湊久美子、家光素行
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-15
• [Presentation] 中里浩一、石井直方.レジスタンストレーニングに伴う骨格筋適応レベルの変化が一過性の筋同化応答に及ぼす影響 (2012)
  • Author(s): 小笠原理紀、小林幸次、蔦木新、李基赫、藤田聡
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-15
• [Presentation] レジスタンス運動後のロイシン高配合必須アミノ酸混合物摂取が筋タンパク質分解の制御に及ぼす影響 (2012)
  • Author(s): 辻野真史、家光素行、佐藤幸治、松谷健司、高橋圭、浜岡隆文、田中賢治、平林由理、小林久峰、藤田聡
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-14
• [Presentation] Effect of reducedtraining frequency on muscle mass andserum testosterone in older men (2012)
  • Author(s): Matsutani K,Sato K,Takahashi K,Tsujino M , Kurihara T , Iemits M ,Hamaoka T,Fujita S
  • Organizer: 17thEUROPEAN COLLEGE of SPORTSCIENCE
  • Place of Presentation: Bruges (Belgium)
  • Year and Date: 2012-07-05
• [Presentation] Low-intensityresistance training using an elastic bandimproves muscle mass and function iolder people (2012)
  • Author(s): Matstani K , Sato K , Iemits M ,Kurihara T,Kimura T,Isaka T,HamaokaT , FACSM, Fujita S
  • Organizer: 59th AMERICANCOLLEGE of SPORTS MEDICINE
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2012-06-02
• [Presentation] Exercise training-induced Improvement of Impairedmuscle glucose metabolism is associatedwith muscular sex steroid hormone level inzucker fatty diabetes rats (2012)
  • Author(s): Sato K,Minato K,Fujita S,YamauchiH , Mesaki N , Iemitsu M
  • Organizer: 59thAMERICAN COLLEGE of SPORTSMEDICINE
  • Place of Presentation: San FranciscoUSA
  • Year and Date: 2012-05-30
• [Presentation] Contraction-induced rpS6 phosphorylation is attenuated after chronicresistance training but recovered aftershort-term detraining (2012)
  • Author(s): Ogasawara R,Kobayashi K,Tsutaki A,Lee K,Abe T,Fujita S,Nakazato K,IshiiN
  • Organizer: 59th AMERICAN COLLEGE of SPORTS MEDICINE
  • Place of Presentation: San Francisco USA
  • Year and Date: 2012-05-30
• [Book] エクササイズ科学体力つくりと疾病・介護予防のための基礎と実践 (2012)
  • Author(s): 藤田聡、伊坂忠夫
  • Total Pages: 279
  • Publisher: 分光堂
• [Book] 健康・運動の科学介護と生活習慣病予防のための運動処方 (2012)
  • Author(s): 藤田聡
  • Total Pages: 189
  • Publisher: 講談社
• [Book] 転倒予防のためのバランス運動の理論と実際 (2010)
  • Author(s): 藤田聡
  • Total Pages: 132
  • Publisher: ナップ