2012 Fiscal Year Final Research Report
Identification of novel tyrosine kinase fusion genes using a unique system based on morphology
| Project/Area Number |
22680063
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnosis
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
TAKEUCHI Kengo 公益財団法人がん研究会, がん研究所病理部, 主任研究員 (40323612)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん / チロシンキナーゼ / 融合遺伝子 |
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| Research Abstract |
We identified PPFIBP1-ALK in inflammatory myofibroblastic tumor and TPM3-ALK and EML4-ALK in renal cell carcinoma. In lymphoma, we found SQSTM1-ALK. KLC1-ALK was identified from a formalin-fixed paraffin-embedded (FFPE) tissue by RACE optimized for FFPE. We established a unique system for identification of fusion genes based on histopathological methods, and identified 4 ROS1 and 2 RET novel fusion genes. We also proposed a new entity of low-grade B-cell lymphoma, which was characterized by IRF4 rearrangement
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