2013 Fiscal Year Final Research Report
Mechanism Verification of the Action of Environmental Chemicals on Brain Development
Project/Area Number |
22681008
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Kumamoto University (2011-2013) The University of Tokyo (2010) |
Principal Investigator |
MIYAZAKI Wataru 熊本大学, 大学院生命科学研究部, 助教 (90512278)
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Project Period (FY) |
2010-04-01 – 2014-03-31
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Keywords | 環境化学物質 / 脳発達 |
Research Abstract |
In this study, we investigated the mechanisms of the adverse effects of environmental chemicals on brain development. To clarify the mechanisms of the effects of the chemicals on neural development, we analyzed that what kind of effects were exerted by exposure of environmental using mice hippocampus primary culture cell and human-derived neural progenitor cell line. We observed some changes of gene expression related to neural development. Moreover, we performed mice experiments exposed environmental chemicals. In these study, we observed that the exposure caused several changes of neural circuit and abnormal behaviors. These results suggested that the chemicals disrupt construction of brain and exert abnormal brain development.
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[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage2011
Author(s)
Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M
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Journal Title
Behav Brain Res
Volume: 221(1)
Pages: 172-81
DOI
Peer Reviewed
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