Mechanism Verification of the Action of Environmental Chemicals on Brain Development

2013 Fiscal Year Final Research Report

• Project/Area Number: 22681008
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kumamoto University (2011-2013); The University of Tokyo (2010)
• Principal Investigator: MIYAZAKI Wataru 熊本大学, 大学院生命科学研究部, 助教 (90512278)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 環境化学物質 / 脳発達

Research Abstract

In this study, we investigated the mechanisms of the adverse effects of environmental chemicals on brain development.
To clarify the mechanisms of the effects of the chemicals on neural development, we analyzed that what kind of effects were exerted by exposure of environmental using mice hippocampus primary culture cell and human-derived neural progenitor cell line. We observed some changes of gene expression related to neural development. Moreover, we performed mice experiments exposed environmental chemicals. In these study, we observed that the exposure caused several changes of neural circuit and abnormal behaviors. These results suggested that the chemicals disrupt construction of brain and exert abnormal brain development.

Research Products

• [Journal Article] Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins (2014)
  • Author(s): Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C
  • Journal Title: Arch Toxicol Volume: 88(3) Pages: 789-98
  • DOI: 10.1007/s00204-013-1161-y
  • Peer Reviewed
• [Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage (2011)
  • Author(s): Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M
  • Journal Title: Behav Brain Res Volume: 221(1) Pages: 172-81
  • DOI: 10.1016/j.bbr.2011.02.037
  • Peer Reviewed
• [Journal Article] In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice (2010)
  • Author(s): Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C
  • Journal Title: Neurotoxicology Volume: 31(4) Pages: 385-90
  • DOI: 10.1016/j.neuro.2010.04.004
  • Peer Reviewed
• [Presentation] ヒト胎児由来神経前駆細胞を用いた神経分化に置ける低用量ビスフェノールA の影響 (2013)
  • Author(s): 藤原悠基
  • Organizer: 日本内分泌撹乱化学物質学会
  • Place of Presentation: 東京大学
  • Year and Date: 2013-12-12
• [Presentation] 甲状腺ホルモン受容体を介する転写に置けるAhR, Arntの関与 (2012)
  • Author(s): 宮崎航
  • Organizer: 日本内分泌撹乱化学物質学会
  • Place of Presentation: 東京大学
  • Year and Date: 2012-12-18
• [Presentation] ヒト胎児由来神経前駆細胞からの神経分化における鉛曝露の影響 (2012)
  • Author(s): 宮崎航
  • Organizer: 日本衛生学会第82回学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] Abnormal emotional behavior after maternal exposure to bisphenol A in mice detected by IntelliCage (2011)
  • Author(s): Wataru Miyazaki, et al
  • Organizer: Society of Toxicology
  • Place of Presentation: Washington D.C
  • Year and Date: 2011-03-10
• [Remarks] ホームページ
  • URL: http://kumadai-publich.com