2012 Fiscal Year Final Research Report
roles of serotonin in the body axis formation
| Project/Area Number |
22687016
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
MAEGAWA Shingo 京都大学, 大学院・情報学研究科, 助教 (30467401)
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| Research Collaborator |
FUJIOKA Shunji 京都大学, 大学院・情報学研究科, 修士学生
TOKUMASU Yudai 京都大学, 総合人間学部, 学部生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 形成体 / セロトニン |
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| Research Abstract |
Serotonin is a well-known neurotransmitter involved in sociality and/or behavior of animal. In the present study, we revealed that Tphd2, a serotonin synthesis emzyme, is expressed in the organizer in zebrafish. In addition, serotonin itself is expressed during gastrulation depending on the organizer. Inhibition of Tphd2 by antisense resulted in shortened body axis. Molecular and developmental studies demonstrated that Thpd2 is required for migration of cells toward to the dorsal region during morphogenesis. Finally, the results clearly indicate that serotonin is involved in early body patterning in zebrafish development.
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