2013 Fiscal Year Final Research Report
Investigation of the pathophysiological role of an anti-inflammatory mediator prostaglandin D2.
| Project/Area Number |
22688024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MURATA Takahisa 東京大学, 農学生命科学研究科, 准教授 (40422365)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 薬理 / 炎症 / 病態 / 組織再生 |
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| Research Abstract |
We here investigated the pathophysiological role of an anti-inflammatory mediator prostaglandin D2. We found that 1) integral membrane protein Caveolin-1 modulates prostaglandin synthase activity, 2) urinary metabolite of prostaglandin D2 might be biomarker of various inflammatory diseases, 3) prostaglandin D2 signal enhancement inhibit the progressions of inflammatory diseases, 4) inhibition of prostaglandin D2 synthase leads vascular and tissue regenerations. These observations provide new insights for future therapy against inflammatory diseases and tissue re-generation.
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[Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation2014
Author(s)
Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T
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Journal Title
J Immunol
Volume: 192(1)
Pages: 459-465
DOI
Peer Reviewed
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[Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement2013
Author(s)
Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110(13)
Pages: 5205-5210
DOI
Peer Reviewed
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