2011 Fiscal Year Final Research Report
Blast-induced traumatic brain injury : Mechanism of injury and recovery by brain-machine interface
| Project/Area Number |
22689039
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 衝撃波工学 / レーザー工学 / 高エネルギー外傷 / 対側損傷 / 部外傷モデル / blast injury / アジ化銀 / 高速度撮影 |
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| Research Abstract |
The primary blast-induced traumatic brain injury (bTBI)phase represents the response of brain tissue to the initial blast wave. Among the four phases of bTBI, there is a remarkable paucity of information about the cause of primary bTBI. There is increasing demand to understand mechanism and pathophysiology of bTBI. Understanding the mechanism of blast propagation into skull, and the development of animal model that is validated in terms of shock wave physics and can be conducted on the bench top is a key issue to understand the mechanism, pathophysiology, and to develop proper treatment and protection for this"new" form of TBI.
We have evaluated the mechanism of propagation of blast wave and shock wave in terms of visualization, pressure measurement, and numerical simulation. The experiments in brain phantom revealed that propagated wave through the skull has temporal increase of pressure on the side of wave entry and on the opposite side to the entry. The latter may explain the mechanism of contra coup injury, which is often observed in severe traumatic brain injury. The distribution of wave distribution correlated with the histological damage in animal model experiments.
The results of present investigation not only has impact on understanding the mechanism of blast wave-induced traumatic brain injury, but also helps to develop brain protection methods in traumatic brain injury by high energy traffic accident, and traumatic injury by high pressure waves during natural/industrial disasters.
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[Journal Article] Pulsed laser-induced liquid jet : evolution from shock/bubble interaction to neurosurgical application.2012
Author(s)
Nakagawa A, Kumabe T, Ogawa Y, Hirano T, Nakano T, Watanabe M, Yamamoto H, Ohtani K, Satomi S, Takayama K, Tominaga T
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Journal Title
Shock Waves
Volume: (in press)
Peer Reviewed
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[Journal Article] Hypotension and hypoxia within 72 hours in traumatic brain injury patients : Retrospective analysis of prevalence and impact on hospital discharge death at Japanese tertiary referral hospital2012
Author(s)
Nakagawa A, Furuya K, Washio T, Mugikura S, Kudo D, Arafune T, Mata Mbemba D, Miyamura N, Tateno M, Sato T, Karibe H, Kushimoto S, Tominaga T
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Journal Title
Acta Neurochir (Suppl)
Volume: (in press)
Peer Reviewed
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[Journal Article] Chronological analysis in Tohoku University Hospital during the first 72 hours after the Great East Japan Earthquake2012
Author(s)
Nakagawa A, Furukawa H, Kudo D, Abe Y, Sato D, Washio T, Arafune T, Arii M, Yamanouchi S, Kushimoto S, Tominaga T
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Journal Title
IEEE PULSE
Volume: (in press)
Peer Reviewed
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[Presentation] Hypotension and hypoxia within 72 hours in traumatic brain injury patients : Retrospective analysis of prevalence and impact on hospital discharge death at Japanese tertiary referral hospital.2011
Author(s)
Nakagawa A, Furuya K, Washio T, Mugikura S, Kudo D, Tatsuhiko A, Mata Mbemba Daddy, Miyamura N, Tateno M, Sato T, Karibe H, Kushimoto S, Tominaga T
Organizer
XV International Conference on Brain Edema and Cellular Injury
Place of Presentation
Tokyo
Year and Date
2011-11-24
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