2012 Fiscal Year Final Research Report
Basic research for the understanding of osteoclast-specific systems
| Project/Area Number |
22689048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHINOHARA Masahiro 東京医科歯科大学, 大学院・医歯学総合研究 科, 講師 (60345733)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 破骨細胞 / チロシンキナーゼ / PI3K / 歯周病 / 関節リウマチ / 骨粗しょう症 |
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| Research Abstract |
The aim of this study was the establishment for a novel strategy of the treatment for osteoclast-associated bone diseases such as periodontitis-associated alveolar bone loss, rheumatoid arthritis and osteoporosis. We revealed that a novel Btk inhibitor suppressed osteoclast differentiation and function in vitro and in vivo. Furthermore, we also revealed that genetic inhibition of class IA PI3K in osteoclasts resulted in the inhibition of bone-resorbing activity of osteoclasts. Thus, this study showed that pathways that mediated by a tyrosine kinase Btk and a lipid kinase class IA PI3K in osteoclasts are good therapeutic targets in these diseases in this study.
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[Journal Article] Class IA Phosphatidylinositol 3-kinases regulates osteoclastic bone resorption through Akt-mediated vesicle transport in mice2012
Author(s)
Shinohara M, Nakamura M, Masuda H, Kadono Y, Iwasawa M, Nagase Y, Ueki K, Kadowaki T, Sasaki T, Kato S, Nakamura H, Nakamura K, Tanaka S, Takayanagi H
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 2464-2475
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[Journal Article] TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis.2012
Author(s)
Otero K#, Shinohara M#, Zhao H#, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M.
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Journal Title
J Immunol
Volume: 188
Pages: 2612-2621
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