2013 Fiscal Year Final Research Report
Clarification of the mechanism in dental tissue differentiation by using tissue stem cells.
| Project/Area Number |
22689050
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 幹細胞 / 前駆細胞 / 分化メカニズム |
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| Research Abstract |
In order to clarify the tooth tissue differentiation capacity by using a human immature tooth germ, we have performed tooth tissue reconstruction with tooth epithelial tissues and tooth mesenchymal tissues, which were isolated from the human wisdom tooth germs during tooth developmental stage, and transplanted into the immunodeficient animal. The reconstruction with tooth epithelial tissue and tooth mesenchymal tissue were generated a tooth crown structure including enamel and dentin. In addition, the reconstruction with tooth mesenchymal tissue and dental follicle tissue were generated a tooth root structure including cementum and periodontal ligament on the dentin surface. These results showed that the tooth tissue reconstruction using dental stem cells might be regenerated a correct tooth structure by mimicking the tooth development.
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[Journal Article] miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells2013
Author(s)
Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T
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Journal Title
PloS One
Volume: 8(12)
Pages: e83545:1-11
DOI
Peer Reviewed
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[Journal Article] 施設に入所している要介護高齢者の問題点を抽出するチュートリアル演習の試み2011
Author(s)
松香芳三, 縄稚久美子, 木村 彩, 完山 学, 水口 一, 三野卓哉, 丸濱功太郎, 前川賢治, 藤澤拓生, 園山 亘, 峯 篤史, 菊谷 武, 窪木拓男
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Journal Title
老年歯科医学
Volume: 26(1)
Pages: 36-45
Peer Reviewed
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