2011 Fiscal Year Final Research Report
Telencephalin binds to vitronectin and regulates synapse formation
| Project/Area Number |
22700354
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
FURUTANI Yutaka 独立行政法人理化学研究所, シナプス分子機構研究チーム, 研究員 (80392108)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | テレンセファリン / ビトロネクチン / スパイン / シナプス形成 / 細胞接着分子 / 細胞外マトリックス |
|---|
| Research Abstract |
I report the identification of telencephalin as a novel vitronectin receptor on neuronal dendrites. Vitronectin-coated microbeads induce the accumulation of telencephalin and the formation of phagocytic cup-like plasma membrane protrusions on dendrites of cultured hippocampal neurons. Vitronectin-deficient mice displays marked enlargement of spine heads in hippocampal CA1 pyramidal neurons. These results suggest that the vitronectin and its neuronal receptor telencephalin play a pivotal role in spine morphogenesis.
|
-
-
[Journal Article] An Extracellular Transglutaminase is Required for Apple Pollen Tube Growth2010
Author(s)
A. Di Sandro, S. Del Duca, EA. Verderio, AJ. Hargreaves, A. Scarpellini, G. Cai, M. Cresti, C. Faleri, RA. Iorio, S. Hirose, Y. Furutani, IG. Coutts, M. Griffin, PL. Bonner, D. Serafini
-
Journal Title
Biochem J.
Volume: 429
Pages: 261-271
Peer Reviewed
-
-
-
