2011 Fiscal Year Final Research Report
Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
| Project/Area Number |
22700390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UEMURA Takeshi 東京大学, 大学院・医学系研究科, 助教 (00372368)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経伝達物質 / 受容体 |
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| Research Abstract |
The N-terminal domain of glutamate receptor GluRδ2 interacts with neurexins through secreted Cbln1. Cbln1 is a ligand for both GluRδ2 and neurexins. Trans-synaptic interaction of postsynaptic GluRδ2 and presynaptic neurexins through Cbln1 mediates parallel fiber-Purkinje cell synapse formation in the cerebellum.
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