2011 Fiscal Year Final Research Report
Analysis of Cerebellar Motor Learning by Reversal Neurotransmission Blocking Technique
| Project/Area Number |
22700422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2011)
Osaka Bioscience Institute (2010) |
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Principal Investigator |
WADA Norio 公益財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (90525958)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 眼球運動 / 小脳顆粒細胞 / プルキンエ細胞 / 小脳運動学習 / 前庭核 |
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| Research Abstract |
To explore the mechanism of acquisition, retention and expression of motor learning, we investigated roles of the cerebellar cortex and the vestibular nuclei which receive information from the cerebellar cortex. When information transmission from the cerebellar cortex to the vestibular nuclei was blocked, score of motor learning was low. However, when the information transmission was recovered at the second learning test, the score was high. On the contrary, after inducing the motor learning at the first learning test of normal information transmission, the score remained high at the second learning test of blocked information transmission. These results suggest that the cerebellar cortex is necessary for expression of motor learning but not necessary for expression after establishment of the motor learning.
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