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2012 Fiscal Year Final Research Report

Relation between optical intrinsic signal imaging on regulation of microcirculation on mice somatosensory cortex

Research Project

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Project/Area Number 22700441
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fusional brain recording science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

KAWAGUCHI Hiroshi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (60510394)

Research Collaborator ITO Hiroshi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (20360357)
TAKUWA Hiroyuki  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40508347)
KANNO Iwao  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (10360356)
OBATA Takayuki  独立行政法人放射線医学総合研究所, 重粒子医科学センター病院, チームリーダー (00285107)
OKADA Eiji  慶應義塾大学, 理工学部, 教授 (40221840)
MASAMOTO Kazuo  電気通信大学, 先端領域教育研究センター, 特任准教授 (60455384)
Project Period (FY) 2010 – 2012
Keywords生物・生体工学 / 脳微小循環 / 生体医用光学 / 脳血流
Research Abstract

The present study investigated the contributions of the regulation system of micro-level hemodynamics and vasculature on diffuse optical imaging by using multi photon laser scanning microscopy and the development of the software that evaluate the microcirculation. The results indicates that the change in diameter of arterioles is much smaller than that of change in intensity of diffuse optical signal, which suggest the passive change in diameters of capillary and vein, and hematocrit might affect the change in intensity of diffuse optical signal.

  • Research Products

    (9 results)

All 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] Image-based vessel-by-vessel analysis for red blood cell and plasma dynamics with automatic segmentation2012

    • Author(s)
      Hiroshi Kawaguchi, Kazuto Masamoto, Hiroshi Ito, Iwao Kanno
    • Journal Title

      Microvascular Research

      Volume: Volume 84, Issue 2 Pages: 178-187

    • DOI

      doi: 10.1016/j.mvr.2012.05.001

    • Peer Reviewed
  • [Journal Article] Spatial Frequency-Based Analysis of Mean Red Blood Cell Speed in Single Microvessels: Investigation of Microvascular Perfusion in Rat Cerebral Cortex

    • Author(s)
      Joonas Autio, Hiroshi Kawaguchi, Shigeyoshi Saito, Ichio Aoki, Takayuki Obata, Kazuto Masamoto, Iwao Kanno
    • Journal Title

      PLoS ONE

      Volume: Volume 6, Issue 8

    • DOI

      doi:10.1371/journal.pone.0024056

    • Peer Reviewed
  • [Presentation] Comparison between neuromelanin-related MRI signal and dopamine transporter binding measured by PET in humans2013

    • Author(s)
      Hiroshi Kawaguchi
    • Organizer
      XXVIth International Symposium on Cerebral Blood Flow, Metabolism, and Function &. The XIth International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20130520-23
  • [Presentation] 脳微小血管の時空間画像による赤血球速度自動定量法2012

    • Author(s)
      川口拓之
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      広島
    • Year and Date
      20121107-09
  • [Presentation] A semi-automated classification of vascular components in mouse somatosensory cortex from 3d multi-photon laser scanning microscopic image2012

    • Author(s)
      Hiroshi Kawaguchi
    • Organizer
      The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      20120814-17
  • [Presentation] Dependency of Hemodynamic Responses on Vessel Segments Determined by Vessel-Branch-Based Analysis of Vascular Network in Rat Cortex2011

    • Author(s)
      Hiroshi Kawaguchi
    • Organizer
      XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-05-26
  • [Presentation] Dependency of Hemodynamic Responses on Vessel Segments: Vessel-Branch-Based Analysis of Vascular Network in Rat Cortex2010

    • Author(s)
      川口拓之
    • Organizer
      第14回酸素ダイナミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-04
  • [Presentation] Dependency of Hemodynamic Responses on Vessel Segments Determined by Vessel-Branch-Based Analysis of Vascular Network in Rat Cortex2010

    • Author(s)
      Hiroshi Kawaguchi
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Andover, USA
    • Year and Date
      2010-08-26
  • [Presentation] SNPおよび前肢刺激に対する血行動態変化の血管径依存性2010

    • Author(s)
      川口拓之
    • Organizer
      第22回日本脳循環代謝学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-12

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Published: 2014-08-29   Modified: 2015-11-02  

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