2011 Fiscal Year Final Research Report
Quantitative analysis of cerebral neuronal injury induced by impact strain loading
| Project/Area Number |
22700473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Research Collaborator |
UMAHASHI Hiroto 首都大学東京, システムデザイン研究科
FUKUMURA Yohei 首都大学東京, システムデザイン研究科
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| Project Period (FY) |
2010 – 2011
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| Keywords | インパクトバイオメカニクス / 神経損傷 / 衝撃ひずみ / 神経突起伸長制御 |
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| Research Abstract |
Traumatic brain injury is associated with rapid deformation of brain tissue resulting in the stretching of neural axons. In this study, the elongation of neurite was controlled by microfabrication technique for quantitative analysis of neuronal injury. We demonstrated that the degree of injury was correlated with the magnitude of strain along neurite elongation and the rate of injury was higher in neurites oriented in the direction of strain than in neurites oriented in a random pattern.
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