2011 Fiscal Year Final Research Report
The institution of reference nutrient intake on phosphate, aimed prevention for the lifestyle-related disease
| Project/Area Number |
22700750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHUTO Emi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10512121)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生活習慣病 / 慢性炎症 / 動脈硬化 / 高リン血症 |
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| Research Abstract |
Excessive dietary phosphorus(P) has been speculated as a risk factor for cardiovascular disease(CVD) in healthy persons as well as in patients with chronic kidney disease. We reported that high P-loading increased production of reactive oxygen species and decrease nitric oxide(NO) availability in endothelial cells. In addition, we performed dose and time-dependent effect of dietary P intake on endothelial function in healthy male volunteers. High P meals significantly increased serum P levels in a dose-dependent manner, whereas significant decrease in% flow-mediated dilation(% FMD) was observed. Significant negative correlation was also observed between% FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. Habitual excessive P intake and resulting in endothelial dysfunction may contribute to progress CVD or increasing mortality as epidemiologically speculated.
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[Journal Article] Extracts of common buckwheat bran prevent sucrose digestion2011
Author(s)
Hosaka T, Nii Y, Tomotake H, Ito T, Tamanaha A, Yamasaka Y, Sasaga S, Edazawa K, Tsutsumi R, Shuto E, Okahisa N, Iwata S, Sakai T
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Journal Title
J Nutr Sci Vitaminol
Volume: 57(6)
Pages: 441-445
DOI
Peer Reviewed
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