2011 Fiscal Year Final Research Report
Study of the function of the nuclear protein LDOC1 in the regulation of MDM2-mediated p53 ubiquitination
| Project/Area Number |
22700871
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NASU Ryo 東京大学, 分子細胞生物学研究所, 助教 (30466859)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌抑制遺伝子 / 細胞死 / クロマチン / p53 / MDM2 |
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| Research Abstract |
The nuclear protein LDOC1 is found to regulate the expressions of p53-target genes induced by DNA-damaging reagents. Moreover, p53-target genes are divided into the LDOC1-dependent and-independent groups. These data raise the possibility that LDOC1 is involved not only in the regulation of p53 stability but also in the control of the recruitment of p53.
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