2011 Fiscal Year Final Research Report

Study of the function of the nuclear protein LDOC1 in the regulation of MDM2-mediated p53 ubiquitination

Research Project

Project/Area Number	22700871
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Tumor biology
Research Institution	The University of Tokyo
Principal Investigator	NASU Ryo 東京大学, 分子細胞生物学研究所, 助教 (30466859)
Project Period (FY)	2010 – 2011
Keywords	癌抑制遺伝子 / 細胞死 / クロマチン / p53 / MDM2
Research Abstract	The nuclear protein LDOC1 is found to regulate the expressions of p53-target genes induced by DNA-damaging reagents. Moreover, p53-target genes are divided into the LDOC1-dependent and-independent groups. These data raise the possibility that LDOC1 is involved not only in the regulation of p53 stability but also in the control of the recruitment of p53.

(2 results)