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2011 Fiscal Year Final Research Report

Genome-wide exploration of molecular targets for invasion of malignant pleural mesothelioma cell

Research Project

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Project/Area Number 22700882
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor biology
Research InstitutionThe University of Tokushima

Principal Investigator

KAKIUCHI Soji  徳島大学, 病院, 講師 (50380100)

Project Period (FY) 2010 – 2011
Keywords悪性胸膜中皮腫 / 浸潤 / マイクロアレイ
Research Abstract

Genome wide gene expression analysis was performed to compare the human malignant mesothelioma(MPM) cells and their derived cells which had higher invasive capacity. Among the dozens of candidate genes, we focused on gene X, which was commonly down-regulated among highly invasive cells. By knocking down of gene X, invasiveness was accelerated, but proliferation and migration activities were not changed in parental cells. In orthotopic implantation model of MPM, the survival was statistically significantly shorter in gene X knock down group than scramble group, suggesting that gene X might be a target gene for a new treatment against the invasion of MPM.

  • Research Products

    (8 results)

All 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results)

  • [Journal Article] Epidermal growth factor receptor-tyrosine kinase inhibitor(gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats2012

    • Author(s)
      Miyake K, Tani K, Kakiuchi S, Suzuka C, Toyoda Y, Kishi J, Tezuka T, Yuasa S, Hanibuchi M, Aono Y, Nishioka Y, Sone S
    • Journal Title

      J Med Invest

      Volume: 59(1-2) Pages: 174-85

    • Peer Reviewed
  • [Journal Article] Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice2012

    • Author(s)
      Dat le T, Matsuo T, Yoshimaru T, Kakiuchi S, Goto H, Hanibuchi M, Kuramoto T, Nishioka Y, Sone S, Katagiri T
    • Journal Title

      Int J Oncol

    • DOI

      DOI:10.3892/ijo.2012.1348

    • Peer Reviewed
  • [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression2012

    • Author(s)
      Gabr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Moriya Y, Sone S, Nishioka Y
    • Journal Title

      Clin Exp Metastasis

      Volume: 29(3) Pages: 207-16

    • Peer Reviewed
  • [Journal Article] Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital2011

    • Author(s)
      Goto H, Hanibuchi M, Sakaguchi S, Kanematsu T, Kakiuchi S, Tomimoto H, Azuma M, Tezuka T, Tada H, Miki Y, Nakamura T, Sone S, Nishioka Y
    • Journal Title

      J Med Invest

      Volume: 58(3-4) Pages: 219-26

    • Peer Reviewed
  • [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor2011

    • Author(s)
      Ogino H, Hanibuchi M, Kakiuchi S, Trung VT, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S
    • Journal Title

      Mol Cancer Ther

      Volume: 10(7) Pages: 1218-28

    • Peer Reviewed
  • [Journal Article] 5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor2011

    • Author(s)
      Ali AH, Takizawa H, Kondo K, Matsuoka H, Toba H, Nakagawa Y, Kenzaki K, Sakiyama S, Kakiuchi S, Sekido Y, Sone S, Tangoku A
    • Journal Title

      Lung Cancer

      Volume: 74(1) Pages: 48-54

    • Peer Reviewed
  • [Journal Article] Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice2011

    • Author(s)
      Kishi J, Nishioka Y, Kuwahara T, Kakiuchi S, Azuma M, Aono Y, Makino H, Kinoshita K, Kishi M, Batmunkh R, Uehara H, Izumi K, Sone S
    • Journal Title

      Eur Respir J

      Volume: 38(2) Pages: 415-24

    • Peer Reviewed
  • [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice2011

    • Author(s)
      Van TT, Hanibuchi M, Kakiuchi S, Sato S, Kuramoto T, Goto H, Mitsuhashi A, Nishioka Y, Akiyama S, Sone S
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 68(2) Pages: 497-504

    • Peer Reviewed

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Published: 2013-07-31  

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