2011 Fiscal Year Final Research Report
Studies on selective translation mechanism of stress response Protein under global translational repression
| Project/Area Number |
22700892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | 公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010) |
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Principal Investigator |
TSUKUMO Yosinori 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 (40469630)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 翻訳 / ストレス応答タンパク / 小胞体 / mRNA / リボソーム / 翻訳開始因子 / 腫瘍 / 飢餓 |
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| Research Abstract |
Upon endoplasmic reticulum(ER) stress, PKR-like ER-resident kinase(PERK) phosphorylates eukaryotic translation initiation factor 2 alpha(eIF2α), resulting in reducing global translation while promoting translation reinitiation of upstream open reading frame(uORF)-containing mRNAs, such as ATF4.We showed transducin(beta)-like 2(TBL2) as a novel ER-anchored adaptor protein that promotes the PERK-mediated translation reinitiation for cell survival.
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[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation2012
Author(s)
Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
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Journal Title
Molecular Cancer Therapeutics(These authors equally contributed to this work)
Volume: 11
Pages: 1082-91
DOI
Peer Reviewed
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