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2011 Fiscal Year Final Research Report

Innovative development of antibody drug with ultrastructural in vivo imaging

Research Project

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Project/Area Number 22700895
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Tumor immunology
Research InstitutionTohoku University

Principal Investigator

GONDA Kohsuke  東北大学, 大学院・医学系研究科, 講師 (80375435)

Project Period (FY) 2010 – 2011
Keywords抗体療法
Research Abstract

To develop antibody drug with cheap and high medicinal effect, this study aimed to visualize and analyze where and how the effect of antibody drug works in the tumor tissues using 3D imaging with high spatial accuracy. I performed fluorescence in vivo and ex vivo imaging and CT imaging, and then aimed to integrate each imaging data. I succeeded in developing new in vivo imaging system, ex vivo imaging 50μm thickness tumor tissues whose cancer cells activity were well, and CT-imaging with new slica-coating gold nano-particles. Now I am imaging tumor-bearing mice with antibody drug-conjugated fluorescent nano-particles or antibody drug-conjugated slica-coating gold nano-particles using fluorescence in vivo and ex vivo imaging or CT imaging. As the results of these, I obtained a preliminary result in the relationship between EPR effect and antibody drug effect.

  • Research Products

    (27 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (7 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Synthesis of Au. silica core. shell particles by sol. gel process2012

    • Author(s)
      Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
    • Journal Title

      Surf. Engineering

      Volume: 28 Pages: 129-133

    • Peer Reviewed
  • [Journal Article] Fabrication and fluorescence properties of multilayered core-shell particles composed of quantum dot, gadolinium compound, and silica2012

    • Author(s)
      Kobayashi Y, Nozawa T, Nakagawa T, Gonda K, Takeda M, Ohuchi N.
    • Journal Title

      J Materials Science

      Volume: 47 Pages: 1852-1859

    • Peer Reviewed
  • [Journal Article] X-ray Imaging of Newly-Developed Gadolinium Compound/Silica Core-Shell Particle2011

    • Author(s)
      Morimoto H, Minato M, Nakagawa T, Sato M, Kobayashi Y, Gonda K, Takeda M, Ohuchi N, Suzuki N.
    • Journal Title

      Journal of Sol-Gel Science and Technology

      Volume: 59 Pages: 650-657

    • Peer Reviewed
  • [Journal Article] Preparation of silica-coated AgI nanoparticles by an amine-free process and their X-ray imaging properties2011

    • Author(s)
      Ayame T, Kobayashi Y, Nakagawa T, Gonda K, Takeda M, Ohuchi N.
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 119 Pages: 397-401

    • Peer Reviewed
  • [Journal Article] Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties2011

    • Author(s)
      Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
    • Journal Title

      Journal of Colloid & Interface Science

      Volume: 358 Pages: 329-333

    • Peer Reviewed
  • [Journal Article] Single-particle tracking confirms that multivalent Tat-protein transduction domain induced Heparan-sulfate Proteoglycan (HSPG)cross-linkage activates Racl for internalization2011

    • Author(s)
      Imamura J, Suzuki Y, Gonda K, Roy CN, Gatanaga H, Ohuchi N, Higuchi H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Pages: 10581-10592

    • Peer Reviewed
  • [Journal Article] Uniform silica coated fluorescent nanoparticles : Synthetic method, improved light stability and application to visualize lymph network tracer2010

    • Author(s)
      Cong L, Takeda K, Hamanaka Y, Gonda K, Watanabe M, Kumasaka M, Kobayashi Y, Kobayashi M, Ohuchi N.
    • Journal Title

      PLoS ONE

      Volume: 5 Pages: e13167

    • Peer Reviewed
  • [Journal Article] Direct coating of quantum dots with silica shell2010

    • Author(s)
      Kobayashi Y, Nozawa T, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
    • Journal Title

      Journal of Sol-Gel Science and Technology

      Volume: 55 Pages: 79-85

    • Peer Reviewed
  • [Journal Article] Myosin-X induces filopodia by multiple elongation mechanism2010

    • Author(s)
      Watanabe TM, Tokuo H. Gonda K, Higuchi H, Ikebe M.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 19605-19614

    • Peer Reviewed
  • [Journal Article] Nano-imaging of the lymph network structure with quantum dots2010

    • Author(s)
      Hikage M, Gonda K, Takeda M, Kamei T, Kobayashi M, Kumasaka M, Watanabe M, Satomi S, Ohuchi N.
    • Journal Title

      Nanotechnology

      Volume: 21 Pages: 185103

    • Peer Reviewed
  • [Presentation] Development of imaging system for advanced nanomedicine2012

    • Author(s)
      Gonda K, Hikage M, Hamada Y, Nakagawa T, Ohuchi N.
    • Organizer
      5th International Symposium on Nanomedicine
    • Place of Presentation
      Nagoya
    • Year and Date
      20120315-17
  • [Presentation] In vivo molecular imaging of cancer metastasis and angiogenesis in mice using fluorescent nano-particle2011

    • Author(s)
      Gonda K.
    • Organizer
      3^<rd> Global COE International Symposium"New Trends in Basic and Clinical Cancer Research for Innovative Therapy"
    • Place of Presentation
      Nagoya
    • Year and Date
      20111208-09
  • [Presentation] In vivo nano-imaging of cancer metastasis in tumor-bearing mice and angiogenesis in ischemic model mice2011

    • Author(s)
      Gonda K, Hamada Y, Takeda M, and Ohuchi N.
    • Organizer
      Network Medicine Global COE International Minisymposium
    • Place of Presentation
      Sendai
    • Year and Date
      2011-02-04
  • [Presentation] Quantitative analysis of mechanism of cancer metastasis using in vivo nano-imaging with quantum dots2010

    • Author(s)
      Gonda K, Hikage M, Hamada Y, Takeda M, Higuchi H, Ohuchi N.
    • Organizer
      4th International Symposium on Nanomedicine
    • Place of Presentation
      Okazaki
    • Year and Date
      20101129-1201
  • [Presentation] ナノイメージングを用いたがん転移のメカニズム解析と診断法開発2010

    • Author(s)
      権田幸祐、日景允、武田元博、大内憲明
    • Organizer
      実験動物中央研究所組織連携シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2010-12-21
  • [Book] 血管新生における血管内皮増殖因子受容体分布の生体分子イメージング2011

    • Author(s)
      濱田庸、権田幸祐、佐藤成、山家智之、里見進、大内憲明
    • Total Pages
      35-39
    • Publisher
      学進出版
  • [Book] 見つけることに意義がある-1分子計測の可能性-2011

    • Author(s)
      上村想太郎、小澤岳昌、加地範匡、権田幸祐
    • Total Pages
      26-30
    • Publisher
      東京化学同人
  • [Book] ナノイメージングで探るがん転移の仕組み2011

    • Author(s)
      権田幸祐、樋口秀男、渡邉朋信、武田元博、大内憲明
    • Total Pages
      50-57
    • Publisher
      メディカルレビュー社
  • [Book] 量子ドットを用いたリンパ節ネットワークの微細構造イメージング2010

    • Author(s)
      日景允、権田幸祐、武田元博、亀井尚、小林正樹、熊坂増高、濱中洋平、濱田庸、中川智彦、宮田剛、大内憲明
    • Total Pages
      13-17
    • Publisher
      学進出版
  • [Book] ナノサイズ抗がん剤の創薬へ応用可能なin vivoナノイメージング法の開発2010

    • Author(s)
      権田幸祐
    • Total Pages
      113-115
    • Publisher
      佐々木出版
  • [Book] Fluorescent sentinel lymph node biopsy under endoscopic surgery using nano-objects2010

    • Author(s)
      日景允, 権田幸祐, 武田元博, 亀井尚, 大内憲明
    • Total Pages
      91-94
    • Publisher
      佐々木出版
  • [Book] 蛍光ナノトレーサーを用いたセンチネルリンパ節生検2010

    • Author(s)
      武田元博, 日景允, 権田幸祐, 叢莉蔓, 大内憲明
    • Total Pages
      33-36
    • Publisher
      メディカルレビュー社
  • [Remarks]

    • URL

      http://www.med.tohoku.ac.jp/org/contribute/107/index.html

  • [Patent(Industrial Property Rights)] 抗体を成分として含む医薬品の有効性の判定方法2011

    • Inventor(s)
      宮下穣、権田幸祐、武田元博、大内憲明
    • Industrial Property Rights Holder
      宮下穣、権田幸祐、武田元博、大内憲明
    • Industrial Property Number
      特許、PCT/JP2011/004763
    • Filing Date
      2011-08-26
    • Overseas
  • [Patent(Industrial Property Rights)] がん発症又はがん発症リスクの判定方法2011

    • Inventor(s)
      権田幸祐、宮下穣、武田元博、大内憲明
    • Industrial Property Rights Holder
      権田幸祐、宮下穣、武田元博、大内憲明
    • Industrial Property Number
      特許、PCT/JP2011/004762
    • Filing Date
      2011-08-26
    • Overseas
  • [Patent(Industrial Property Rights)] 抗体を成分として含む医薬品の有効性の判定方法2010

    • Inventor(s)
      宮下穣、権田幸祐、武田元博、大内憲明
    • Industrial Property Rights Holder
      宮下穣、権田幸祐、武田元博、大内憲明
    • Industrial Property Number
      特許、特願2010-209322
    • Filing Date
      2010-09-17
  • [Patent(Industrial Property Rights)] がん発症又はがん発症リスクの判定方法2010

    • Inventor(s)
      権田幸祐、宮下穣、武田元博、大内憲明
    • Industrial Property Rights Holder
      権田幸祐、宮下穣、武田元博、大内憲明
    • Industrial Property Number
      特許、特願2010-196442
    • Filing Date
      2010-09-02

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Published: 2013-07-31  

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