2011 Fiscal Year Final Research Report
Targeting adenovirus for glioma stem cell with adenovirus library
| Project/Area Number |
22700919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical oncology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 遺伝子治療 / グリオーマ / 腫瘍幹細胞 / アデノウィルス / ライブラリー |
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| Research Abstract |
We have developed a direct selection method of targeted vector from peptide library displayed on an adenovial fiber knob(more than 2x105 level) to overcome the limitation that many cell type-specific ligands for targeted adenovirus vectors are unknown. First, glioma stem cells were prepared from glioma cell line(D54), a peptide-display adenovirus library was screened on them and particular peptide sequences were selected.
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