2011 Fiscal Year Final Research Report
Application of CXCR3 expression in T cells for early diagnostics and prevention of malignant mesothelioma
| Project/Area Number |
22700933
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | Okayama University (2011)
Kawasaki Medical School (2010) |
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Principal Investigator |
MAEDA Megumi 岡山大学, 大学院・自然科学研究科, 助教 (20434988)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アスベスト / 悪性中皮腫 / 胸膜プラーク / 抗腫瘍免疫 / ケモカインレセプター / サイトカイン |
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| Research Abstract |
The expression of CXCR3 in peripheral CD4+ T cells was decreased in asbestos-related patients with pleural plaque and malignant mesothelioma, and IFN-γexpression was impaired in only patients with malignant mesothelioma. Additionally, in vitro study showed that IL-17 expression was enhanced while CXCR3 and IFN-γexpression were suppressed by chronic exposure of CD4+ T cells to asbestos. These results suggested that chronic exposure to asbestos might induce impairment of antitumor immune function and promotion of tumor proliferation.
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[Journal Article] Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-22011
Author(s)
Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T
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Journal Title
Am J Respir Cell Mol Biol
Volume: 45
Pages: 470-479
Peer Reviewed
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