2011 Fiscal Year Final Research Report
Development of genetic analysis method for risk diagnosis for multifactorial disease and drug response
| Project/Area Number |
22710191
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical genome science
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
NISHIDA Nao 独立行政法人国立国際医療研究センター, 肝炎・免疫研究センター, 上級研究員 (50456109)
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| Project Period (FY) |
2010 – 2011
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| Keywords | SNP / タイピング / 多因子疾患 / 個別化医療 |
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| Research Abstract |
High-throughput and highly accurate SNP typing platforms are required to perform risk diagnosis for multifactorial disease and drug response. Here, we improve the DigiTag2 assay to shorten the running time and save the running cost by applying new type of enzyme. The DigiTag2 assay enables analysis of a set of 96 SNPs using Kapa 2GFast HotStart DNA polymerase with a new protocol that has a total running time of about 7 hours, which is 6 hours shorter than the previous protocol.
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[Presentation] A genome-wide association study identifies the ass ociation of HLA-DP locus with chro nic hepatitis B and viral clearance2011
Author(s)
Nishida N, Sawai H, Mawatari Y, Y amaoka M, Koike A, Matsuura K, T anaka Y, Sugiyama M, Ito K, Mizok ami M, Tokunaga K
Organizer
International Congress of Human G enetics 2011(61th Annual ASHG Meeting)
Place of Presentation
Montr eal
Year and Date
20111011-15
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[Presentation] B型肝炎慢性化、B型肝炎ウイルス排除を規定するHLA-DP遺伝子の同定2011
Author(s)
西田奈央,田中靖人,澤井裕美,杉山真也,馬渡頼子,提嶋恵美,小笠原有子,石橋良美,馬場菜津美,溝上雅史,徳永勝士
Organizer
日本分子生物学会
Place of Presentation
パシフィコ横浜
Year and Date
2011-12-14
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