2011 Fiscal Year Final Research Report
Development of the catalyst featured by chemicallyπ-space for asymmetric Suzuki-Miyaura reaction
| Project/Area Number |
22750097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Ryukoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 不斉クロスカップリング / 軸不斉ビアリール / 不斉触媒 / 不斉ホスホナイト化合物 |
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| Research Abstract |
Development of a catalyst that promotes reaction time and catalyst turnover in asymmetric Suzuki-Miyaura cross-coupling reactions was conducted in this research. The novel hexaarylbenzene-based phosphonite ligands which have chiral BINOL moieties were successfully synthesized : one of them has achieved to cross-couple 2-chlro-3-methoxybenzaldehyde with ortho-tolylboronic acid in TON 750 for 4 h, giving 75% and 76% ee. On the other hand, the elaboration was found in the reactions of sterically hindered substrates and the further development of phosphonite ligands.
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