2011 Fiscal Year Final Research Report
Development of artificial aminoacylated tRNA with high efficiency of turnover
| Project/Area Number |
22750146
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
OHKUBO Akihiro 東京工業大学, 大学院・生命理工学研究科, 助教 (60376960)
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| Project Period (FY) |
2010 – 2011
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| Keywords | RNA合成 / アミノアシルtRNA / ホスホロアミダイト法 / アミノ酸 / 固相合成 |
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| Research Abstract |
In this study we could synthesize base-labile aminoacylated RNA oligonucleotides using N-unprotected 5'-phosphoramidite RNA units on the nucleoside-loaded polymer supports via a silyl linker which can be cleaved under neutral conditions. These results have prompted us to study the property of the RNA complexes between the aminoasylated RNAs and corresponding 5'-long RNAs. These additional studies are now underway.
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[Journal Article] Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue : crystal structures of DNA duplexes containing 7, 8-dihydropyrido[ 2, 3-d] pyrimidin-2-one. E. C. M. Juan2010
Author(s)
S. Shimizu, X. Ma, T. Kurose, T. Haraguchi, F. Zhang, M. Tsunoda, A. Ohkubo, M. Sekine, T. Shibata, C. L. Millington, D. M. Williams, A. Takenaka
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Journal Title
Nucleic Acids Res
Volume: 38
Pages: 6737-6745
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